ANGPTL4 - angiopoietin like 4 Gene

Homo sapiens

Also known as NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158

Gene ID: 51129 | Gene type: protein coding

About ANGPTL4

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,364,155-8,374,370 (from NCBI)

This gene has 11 transcripts (splice variants), 240 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in liver (RPKM 42.4), fat (RPKM 23.7) and 17 other tissues.

Summary

This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and Insulin sensitivity. This protein can also act as an Apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013]

ANGPTL4 Products(2)

mRNA	Protein	Name
NM_001039667.3	NP_001034756.1	angiopoietin-related protein 4 isoform b precursor
NM_139314.3	NP_647475.1	angiopoietin-related protein 4 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19028676	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21397862	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	10698685	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	19542565	GOA
involved in protein unfolding	IDA IDA: Inferred from direct assay	29899144	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	10698685	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10698685	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL4 Protein Structure

Fibrinogen_C

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

angiopoietin-related protein 4

PPARG angiopoietin related protein

ANGPTL4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANGPTL4	Q9BY76	ITGB5	Homo sapiens	P18084	Anti Bait CoIP	21397862
Intra	ANGPTL4	Q9BY76	NMT2	Homo sapiens	O60551	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	LPL	Homo sapiens	P06858	ELISA	19318355
Intra	ANGPTL4	Q9BY76	ANGPTL4	Homo sapiens	Q9BY76	GMS	19028676
Intra	ANGPTL4	Q9BY76	PM20D2	Homo sapiens	Q8IYS1	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	AASDHPPT	Homo sapiens	Q9NRN7	Anti Tag CoIP	33961781
Intra	ANGPTL4	Q9BY76	PM20D2	Homo sapiens	Q8IYS1	Anti Tag CoIP	28514442
Intra	ANGPTL4	Q9BY76	AASDHPPT	Homo sapiens	Q9NRN7	Anti Tag CoIP	28514442
Intra	ANGPTL4	Q9BY76	ITGB1	Homo sapiens	P05556	PLA	21397862
Intra	ANGPTL4	Q9BY76	NMT2	Homo sapiens	O60551	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ANGPTL4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7507	ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)	Q9BY76-1(P166-S406)	≥95%
HY-P700562	ANGPTL4/Angiopoietin-related 4 Protein, Human (GST)	Q9BY76-1 (V28-E403)	≥95%

Related Diseases

Diseases

Alias

Plasma Triglyceride Level Quantitative Trait Locus

TGQTL

Plasma Triglyceride Level Qtl, Low

Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Endometrial Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of Endometrium

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Mesenteric Lymphadenitis

Mesenteric Adenitis

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Familial Lipoprotein Lipase Deficiency

Familial Lpl Deficiency	Familial Hyperchylomicronemia
Hyperlipoproteinemia Type I	Familial Hyperlipoproteinemia Type I
Hyperchylomicronemia	Burger-Grutz Syndrome
Endogenous Hypertriglyceridaemia	Familial Fat-Induced Hypertriglyceridemia
Lipd Deficiency	Lpl Deficiency
Lipase D Deficiency	Lipoprotein Lipase Deficiency, Familial
Familial Chylomicronemia Syndrome	Fredrickson Type I Hyperlipoproteinemia
Fredrickson Type I Lipaemia	Hypercholesterinaemic Xanthomatosis
Mixed Hyperglyceridemia	Lipoprotein Lipase Deficiency
Type I Hyperlipoproteinemia	Hyperlipoproteinemia Type Ia
Familial Hyperlipo-Proteinemia Type 1

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diabetes Mellitus

Diabetes

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116247	ST247	Agonist	99.88%	Unkown
HY-RS00693	ANGPTL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990335	Anti-ANGPTL4 Antibody		/	Unkown
HY-P990336	Anti-ANGPTL8 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANGPTL4	VGNC	VGNC:37860
Mus musculus	ANGPTL4	MGD	MGI:1888999
Rattus norvegicus	ANGPTL4	RGD	RGD:735058
Felis catus	ANGPTL4	VGNC	VGNC:59780
Bos taurus	ANGPTL4	VGNC	VGNC:25893
Macaca mulatta	ANGPTL4	VGNC	VGNC:108464
Macaca fascicularis	ANGPTL4	NCBI	NCBI:102135390
Others	ANGPTL4	NCBI

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