COPS4 - COP9 signalosome subunit 4 Gene

Homo sapiens

Also known as CSN4; SGN4

Gene ID: 51138 | Gene type: protein coding

About COPS4

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:83,035,183-83,075,818 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues.

Summary

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

COPS4 Products(3)

mRNA	Protein	Name
NM_001258006.2	NP_001244935.1	COP9 signalosome complex subunit 4 isoform 2
NM_001330727.2	NP_001317656.1	COP9 signalosome complex subunit 4 isoform 3
NM_016129.3	NP_057213.2	COP9 signalosome complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in protein deneddylation	IMP IMP: Inferred from mutant phenotype	21102408	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	24421388	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24421388	GOA
located in synaptic vesicle	IDA IDA: Inferred from direct assay	21102408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS4 Protein Structure

PCI

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

COP9 signalosome complex subunit 4

COP9 constitutive photomorphogenic homolog subunit 4

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V	Xp5
Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype	Xpe
Xp, Group E	Xeroderma Pigmentosum, Type 5
Xeroderma Pigmentosum Complementation Group E	XP-E
Xp Group E

Sulfonamide Allergy

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03029	COPS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	COPS4	RGD	RGD:1302952
Canis familiaris	COPS4	VGNC	VGNC:39511
Felis catus	COPS4	VGNC	VGNC:61089
Bos taurus	COPS4	VGNC	VGNC:27601
Macaca mulatta	COPS4	VGNC	VGNC:71183
Mus musculus	COPS4	MGD	MGI:1349414

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