PAIP2 - poly(A) binding protein interacting protein 2 Gene

Homo sapiens

Also known as PAIP-2; PAIP2A

Gene ID: 51247 | Gene type: protein coding

About PAIP2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:139,341,854-139,369,717 (from NCBI)

This gene has 8 transcripts (splice variants), 192 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 45.2), adrenal (RPKM 41.5) and 25 other tissues.

Summary

Enables translation repressor activity. Involved in negative regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PAIP2 Products(2)

mRNA	Protein	Name
NM_001033112.3	NP_001028284.1	polyadenylate-binding protein-interacting protein 2
NM_016480.5	NP_057564.3	polyadenylate-binding protein-interacting protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11172725	GOA
enables translation repressor activity	IDA IDA: Inferred from direct assay	11172725	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of translational initiation	IDA IDA: Inferred from direct assay	11172725	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11172725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAIP2 Protein Structure

PAM2

0
100
127 a.a.

Protein Preferred Names

Protein Names

polyadenylate-binding protein-interacting protein 2

PABC1-interacting protein 2

Related Diseases

Diseases

Alias

Myoclonic Epilepsy, Juvenile 3

Myoclonic Epilepsy, Juvenile, Susceptibility To, 3	EJM3
Epilepsy, Juvenile Myoclonic 3	Juvenile Myoclonic Epilepsy 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09982	PAIP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAIP2	MGD	MGI:1915119
Rattus norvegicus	PAIP2	RGD	RGD:1359176
Bos taurus	PAIP2	VGNC	VGNC:53573
Felis catus	PAIP2	VGNC	VGNC:102278
Macaca mulatta	PAIP2	VGNC	VGNC:110446

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