1. Gene
  2. PDZD11 - PDZ domain containing 11 Gene

PDZD11 - PDZ domain containing 11 Gene

Homo sapiens

Also known as PISP; AIPP1; PDZK11

Gene ID: 51248 | Gene type: protein coding

About PDZD11

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,286,595-70,289,927 (from NCBI)

This gene has 6 transcripts (splice variants), 215 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 12.6), thyroid (RPKM 10.9) and 25 other tissues.

Summary

Enables protein C-terminus binding activity. Involved in pore complex assembly. Located in basolateral plasma membrane and cytosol. Part of pore complex. [provided by Alliance of Genome Resources, Apr 2022]

PDZD11 Products(6)

mRNA Protein Name
NM_001370174.1 NP_001357103.1 PDZ domain-containing protein 11 isoform 1
NM_001370175.1 NP_001357104.1 PDZ domain-containing protein 11 isoform 1
NM_001370176.1 NP_001357105.1 PDZ domain-containing protein 11 isoform 1
NM_001370177.1 NP_001357106.1 PDZ domain-containing protein 11 isoform 1
NM_001370178.1 NP_001357107.1 PDZ domain-containing protein 11 isoform 2
NM_016484.5 NP_057568.1 PDZ domain-containing protein 11 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12763866 GOA
Biological Process GO Annotation Evidence Reference Source
involved in pore complex assembly IMP
IMP: Inferred from mutant phenotype
30463011 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12763866 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12763866 GOA
part of pore complex IMP
IMP: Inferred from mutant phenotype
30463011 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDZD11 Protein Structure

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (48 - 124)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

PDZ domain-containing protein 11

ATPase-interacting PDZ protein

PDZD11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Y2H Prey Pooling
32296183
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Validated Y2H
32296183
Intra
PDZD11 Q5EBL8 MAGI2 Homo sapiens Q86UL8-2
Y2H Array
32296183
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Pull Down
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Y2H
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Confocal
21183659
Intra
PDZD11 Q5EBL8 SLC5A6 Homo sapiens Q9Y289
Anti Tag CoIP
21183659
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Anti Tag CoIP
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H Pooling
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H Array
16051599
Intra
PDZD11 Q5EBL8 ATP7A Homo sapiens Q04656
Y2H
16051599
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Array
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Validated Y2H
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Prey Pooling
32296183
Intra
PDZD11 Q5EBL8 PLEKHA5 Homo sapiens Q9HAU0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDZD11 Proteins

Cat. No. Product Name Accession Purity
HY-P77130 PDZD11 Protein, Human (His) Q5EBL8-1 (D2-H140) ≥95%

Related Diseases

Diseases Alias
Purulent Acute Otitis Media

Acute Suppurative Otitis Media

Acute Or Subacute Suppurative Otitis Media

Acute Or Subacute Purulent Otitis Media

Epiphyseal Dysplasia, Multiple, 2

EDM2

Multiple Epiphyseal Dysplasia 2

Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly
Epiphyseal Dysplasia, Multiple, 3

EDM3

Multiple Epiphyseal Dysplasia 3

Epiphyseal Dysplasia, Multiple, 3, With Or Without Myopathy

Multiple Epiphyseal Dysplasia 3 With Or Without Myopathy

Epiphyseal Dysplasia Multiple 3

Dysplasia, Epiphyseal, Multiple, Type 3

Multiple Epiphyseal Dysplasia

Med

Polyepiphyseal Dysplasia

Edm

Epiphyseal Dysplasia, Multiple, 1

Epiphyseal Dysplasia, Multiple, 2

Epiphyseal Dysplasia, Multiple, 3

Epiphyseal Dysplasia, Multiple, 4

Epiphyseal Dysplasia, Multiple, 5

Epiphyseal Dysplasia, Multiple

Edm1

Edm2

Edm3

Edm4

Edm5

Epiphyseal Dysplasia, Fairbank Type

Epiphyseal Dysplasia, Ribbing Type

Multiple Epiphyseal Dysplasia, Autosomal Dominant

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Rmed

Dysplasia, Epiphyseal, Multiple

Osteochondrodysplasias

Suppurative Otitis Media

Otitis Media With Effusion - Purulent

Purulent Otitis Media

Otitis Media, Suppurative

Osteochondrodysplasia

Skeletal Dysplasia

Chondrodystrophy

Congenital Anomaly Of Cartilage

Osteochondrodysplasias

Cartilage Development Disorder

Osteochondrodysplasia Syndrome

Dysplasia, Skeletal

Mucopolysaccharidosis Iv

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PDZD11 VGNC VGNC:32724
Mus musculus PDZD11 MGD MGI:1919871
Rattus norvegicus PDZD11 RGD RGD:1560007
Canis familiaris PDZD11 VGNC VGNC:44399
Others PDZD11 NCBI