LHX6 - LIM homeobox 6 Gene

Homo sapiens

Also known as hLHX6; LHX6.1

Gene ID: 26468 | Gene type: protein coding

About LHX6

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:122,202,582-122,228,957 (from NCBI)

This gene has 12 transcripts (splice variants), 265 orthologues and 20 paralogues. Broad expression in fat (RPKM 1.9), brain (RPKM 1.8) and 20 other tissues.

Summary

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

LHX6 Products(6)

mRNA	Protein	Name
NM_001242333.2	NP_001229262.1	LIM/homeobox protein Lhx6 isoform 3
NM_001242334.2	NP_001229263.1	LIM/homeobox protein Lhx6 isoform 4
NM_001242335.2	NP_001229264.1	LIM/homeobox protein Lhx6 isoform 5
NM_001348190.2	NP_001335119.1	LIM/homeobox protein Lhx6 isoform 6
NM_014368.5	NP_055183.2	LIM/homeobox protein Lhx6 isoform 1
NM_199160.4	NP_954629.2	LIM/homeobox protein Lhx6 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHX6 Protein Structure

LIM

Homeobox

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

LIM/homeobox protein Lhx6

LIM homeodomain protein 6.1

LHX6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LHX6	Q9UPM6	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	LHX6	Q9UPM6	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	LHX6	Q9UPM6	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	LHX6	Q9UPM6	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	LHX6	Q9UPM6	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	LDB1	Homo sapiens	Q86U70	BioID	35140242
Intra	LHX6	Q9UPM6	LDB1	Homo sapiens	Q86U70	Affinity Chrom	35140242
Intra	LHX6	Q9UPM6	LDB1	Homo sapiens	Q86U70	Validated Y2H	25416956
Intra	LHX6	Q9UPM6	LDB1	Homo sapiens	Q86U70	Y2H Array	25416956
Intra	LHX6	Q9UPM6	LDB1	Homo sapiens	Q86U70	Anti Tag CoIP	33961781
Intra	LHX6	Q9UPM6	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	LHX6	Q9UPM6	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	LHX6	Q9UPM6	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	LHX6	Q9UPM6	PHYH	Homo sapiens	O14832	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Geotrichosis

Retinitis Pigmentosa 58

RP58	Retinitis Pigmentosa, Type 58

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07636	LHX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LHX6	MGD	MGI:1306803
Bos taurus	LHX6	VGNC	VGNC:30876
Macaca mulatta	LHX6	VGNC	VGNC:74100
Canis familiaris	LHX6	VGNC	VGNC:42667
Felis catus	LHX6	VGNC	VGNC:63224
Rattus norvegicus	LHX6	RGD	RGD:1306174

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