2. Gene
  3. LRIF1 - ligand dependent nuclear receptor interacting factor 1 Gene

LRIF1 - ligand dependent nuclear receptor interacting factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RIF1; FSHD3; HBiX1; C1orf103

Gene ID: 55791 | Gene type: protein coding

About LRIF1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,874,957-110,963,922 (from NCBI)

This gene has 3 transcripts (splice variants), 170 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 11.6), ovary (RPKM 5.5) and 24 other tissues.

Summary

Predicted to enable retinoic acid receptor binding activity. Involved in dosage compensation by inactivation of X chromosome. Located in Barr body; centriolar satellite; and nucleoplasm. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

LRIF1 Products(2)

mRNA Protein Name
NM_001006945.2 NP_001006946.1 ligand-dependent nuclear receptor-interacting factor 1 isoform 2
NM_018372.4 NP_060842.3 ligand-dependent nuclear receptor-interacting factor 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
Biological Process GO Annotation Evidence Reference Source
involved in dosage compensation by inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
23542155 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Barr body IDA
IDA: Inferred from direct assay
23542155 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ligand-dependent nuclear receptor-interacting factor 1

HP1-binding protein enriched in inactive X chromosome protein 1

LRIF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 SPATA18 Homo sapiens Q8TC71
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Bait CoIP
23542155
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Tag CoIP
26496610
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Y2H Array
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Y2H
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Y2H
21900206
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Facioscapulohumeral Muscular Dystrophy 3, Digenic

FSHD3
Facioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy 2

FSHD2

Fshd1b

Facioscapulohumeral Muscular Dystrophy 1b

Fshd2, Digenic

Muscular Dystrophy, Facioscapulohumeral, Type 2

Muscular Dystrophy, Facioscapulohumeral, Type 1b

Fascioscapulohumeral Muscular Dystrophy 2, Digenic

Facioscapulohumeral Muscular Dystrophy Type 2

Digenic Facioscapulohumeral Muscular Dystrophy

Digenic Fshd2

Facioscapulohumeral Muscular Dystrophy Type 1b

Dystrophy, Muscular, Facioscapulohumeral, Type 2
Facioscapulohumeral Muscular Dystrophy 1

Facioscapulohumeral Muscular Dystrophy

Fshd

Landouzy-Dejerine Muscular Dystrophy

Muscular Dystrophy, Facioscapulohumeral

FSHD1

Fshd1a

Muscular Dystrophy, Facioscapulohumeral, Type 1a

Facioscapulohumeral Muscular Dystrophy Type 1a

Fsh Muscular Dystrophy

Facioscapulohumeral Muscular Dystrophy 1a

Facioscapulohumeral Atrophy

Facioscapulohumeral Myopathy

Muscular Dystrophy, Facioscapulohumeral, Type 1

Facioscapulohumeral Muscular Dystrophy Type 1

Landouzy Dejerine Muscular Dystrophy

Muscular Dystrophy, Landouzy-Dejerine

Fshmd1a

Facio-Scapulo-Humeral Dystrophy

Facioscapulohumeral Type Progressive Muscular Dystrophy

Facioscapuloperoneal Muscular Dystrophy

Facioscapulohumeral Dystrophy

Fsh Dystrophy

Landouzy-Dejerine Dystrophy

Landouzy-Dejerine Myopathy

Fmd

Facioscapulohumeral Muscular Dystrophy-1a

Muscular Dystrophy Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral

Dystrophy, Muscular, Facioscapulohumeral, Type 1

Landouzy-Dejerine Disease

Landouzy-Déjerine Atrophy

Facioscapulohumeral Muscle Dystrophy

Fmd - [Facioscapulohumeral Muscular Dystrophy]

Fsh - [Facioscapulohumeral Muscular Dystrophy]

Fshd - [Facioscapulohumeral Muscular Dystrophy]

Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

Landouzy-Déjérine Muscular Dystrophy
Digenic Disease
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome

Immunodeficiency Syndrome, Variable

Ciid

Centromeric Instability, Immunodeficiency Syndrome

Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

Icf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07786 LRIF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRIF1 MGD MGI:2445214
Bos taurus LRIF1 VGNC VGNC:30981
Rattus norvegicus LRIF1 RGD RGD:1306520
Felis catus LRIF1 VGNC VGNC:63280
Macaca mulatta LRIF1 VGNC VGNC:74406
Canis familiaris LRIF1 VGNC VGNC:42766