2. Gene
  3. ATP5F1D - ATP synthase F1 subunit delta Gene

ATP5F1D - ATP synthase F1 subunit delta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ATP5D; MC5DN5

Gene ID: 513 | Gene type: protein coding

About ATP5F1D

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,241,751-1,244,825 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 30.9), colon (RPKM 30.8) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

ATP5F1D Products(2)

mRNA Protein Name
NM_001001975.2 NP_001001975.1 ATP synthase subunit delta, mitochondrial precursor
NM_001687.5 NP_001678.1 ATP synthase subunit delta, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence Reference Source
involved in aerobic respiration IMP
IMP: Inferred from mutant phenotype
29478781 GOA
involved in mitochondrial proton-transporting ATP synthase complex assembly IMP
IMP: Inferred from mutant phenotype
29478781 GOA
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence Reference Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5F1D Protein Structure

ATP-synt_DE_N

ATP-synt_DE_N: ATP synthase, Delta/Epsilon chain, beta-sandwich domain (38 - 119)

  • 0
  • 100
  • 168 a.a.
Protein Preferred Names Protein Names

ATP synthase subunit delta, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

ATP5F1D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATP5F1D P30049 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra
ATP5F1D P30049 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
ATP5F1D P30049 SRSF11 Homo sapiens Q05519-2
Validated Y2H
32296183
Intra
ATP5F1D P30049 SRSF11 Homo sapiens Q05519-2
Y2H Array
32296183
Intra
ATP5F1D P30049 SRSF11 Homo sapiens Q05519-2
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
ATP5F1D P30049 ATP5F1E Homo sapiens P56381
Anti Tag CoIP
33961781
Intra
ATP5F1D P30049 ATP5F1E Homo sapiens P56381
Anti Tag CoIP
28514442
Intra
ATP5F1D P30049 ATP5F1E Homo sapiens P56381
Validated Y2H
32296183
Intra
ATP5F1D P30049 ATP5F1E Homo sapiens P56381
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 ATP5F1E Homo sapiens P56381
Y2H Array
32296183
Intra
ATP5F1D P30049 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ATP5F1D P30049 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ATP5F1D P30049 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
ATP5F1D P30049 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
ATP5F1D P30049 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
ATP5F1D P30049 TNS2 Homo sapiens Q63HR2
Y2H Array
32296183
Intra
ATP5F1D P30049 TNS2 Homo sapiens Q63HR2
Y2H Prey Pooling
32296183
Intra
ATP5F1D P30049 TNS2 Homo sapiens Q63HR2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ATP5F1D Proteins

Cat. No. Product Name Accession Purity
HY-P72097 ATP5D Protein, Human (His-SUMO) P30049 (A23-E168) ≥95%
HY-P72098 ATP5D Protein, Human (His) P30049 (A23-E168) ≥95%

Related Diseases

Diseases Alias
Mitochondrial Complex V Deficiency, Nuclear Type 5

Mitochondrial Complex V Deficiency

MC5DN5

Mitochondrial Complex V Deficiency, Atp5f1d Type

Mitochondrial Complex V Deficiency

Mitochondrial Complex 5 Deficiency Nuclear Type 5

Complex 5 Mitochondrial Respiratory Chain Deficiency

Atp Synthase Deficiency

Mitochondrial Complex V Deficiency, Nuclear Type 5

Complex V Deficiency
Isolated Atp Synthase Deficiency

Isolated Mitochondrial Respiratory Chain Complex V Deficiency
Mitochondrial Disease

Mitochondrial Diseases

Mitochondrial Disorder
3-Methylglutaconic Aciduria

3-Methyl Glutaconic Aciduria
Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30

CILD30

Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus

Primary Ciliary Dyskinesia 30 Without Situs Inversus

Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, Type 30
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01205 ATP5F1D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATP5F1D VGNC VGNC:102003
Rattus norvegicus ATP5F1D RGD RGD:621372
Macaca mulatta ATP5F1D VGNC VGNC:108475
Canis familiaris ATP5F1D VGNC VGNC:38264
Mus musculus ATP5F1D MGD MGI:1913293
Bos taurus ATP5F1D VGNC VGNC:26302