MS4A4A - membrane spanning 4-domains A4A Gene

Homo sapiens

Also known as MS4A4; MS4A7; 4SPAN1; CD20L1; CD20-L1; HDCME31P

Gene ID: 51338 | Gene type: protein coding

About MS4A4A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,280,666-60,308,970 (from NCBI)

This gene has 18 transcripts (splice variants), 118 orthologues and 16 paralogues. Broad expression in placenta (RPKM 28.4), gall bladder (RPKM 18.9) and 20 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features, similar intron/exon splice boundaries, and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

MS4A4A Products(3)

mRNA	Protein	Name
NM_001243266.2	NP_001230195.1	membrane-spanning 4-domains subfamily A member 4A isoform 3
NM_024021.4	NP_076926.2	membrane-spanning 4-domains subfamily A member 4A isoform 2
NM_148975.3	NP_683876.1	membrane-spanning 4-domains subfamily A member 4A isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30833792	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	31413141	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	31413141	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23874341	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	31413141	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A4A Protein Structure

CD20

0
100
200
239 a.a.

Protein Preferred Names

Protein Names

membrane-spanning 4-domains subfamily A member 4A

CD20 antigen-like 1

MS4A4A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MS4A4A	Q96JQ5	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	MS4A4A	Q96JQ5	RPRM	Homo sapiens	Q9NS64	Complementation	32296183
Intra	MS4A4A	Q96JQ5	LPAR3	Homo sapiens	Q9UBY5	Validated Y2H	32296183
Intra	MS4A4A	Q96JQ5	NRG1	Homo sapiens	Q02297-10	Y2H Array	32296183
Intra	MS4A4A	Q96JQ5	NRG1	Homo sapiens	Q02297-10	Y2H Prey Pooling	32296183
Intra	MS4A4A	Q96JQ5	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	MS4A4A	Q96JQ5	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	MS4A4A	Q96JQ5	CSE1L	Homo sapiens	P55060	Pull Down	30833792
Intra	MS4A4A	Q96JQ5	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	MS4A4A	Q96JQ5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	MS4A4A	Q96JQ5	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	MS4A4A	Q96JQ5	SEC22A	Homo sapiens	Q96IW7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 4

AD4	Alzheimer Disease-4
Alzheimer'S Disease 4	Alzheimer Disease, Familial, 4
Alzheimer Disease, Familial4	Alzheimer'S Disease 4, Early Onset
Alzheimer Disease, Type 4

Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma	Chromophobe Carcinoma Of Kidney
Kidney Chromophobe	Renal Cell Carcinoma, Chromophobe Cell
Crcc	Chrcc
Chromophobe Renal Cell Adenocarcinoma	Chromophobe Renal Carcinoma
Chromophobe Carcinoma

Uterine Corpus Cancer

Corpus Uteri Cancer

Malignant Uterine Corpus Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08702	MS4A4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MS4A4A	VGNC	VGNC:104706
Rattus norvegicus	MS4A4A	RGD	RGD:1307006
Mus musculus	MS4A4A	MGD	MGI:3643932

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