ZBTB7A - zinc finger and BTB domain containing 7A Gene

Homo sapiens

Also known as LRF; FBI1; FBI-1; TIP21; ZBTB7; MNDLFH; ZNF857A; pokemon

Gene ID: 51341 | Gene type: protein coding

About ZBTB7A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,043,303-4,066,899 (from NCBI)

This gene has 2 transcripts (splice variants), 114 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues.

Summary

Enables several functions, including SMAD binding activity; Androgen Receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB7A Products(2)

mRNA	Protein	Name
NM_001317990.2	NP_001304919.1	zinc finger and BTB domain-containing protein 7A
NM_015898.4	NP_056982.1	zinc finger and BTB domain-containing protein 7A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17595526	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12004059	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	26455326	GOA
enables SMAD binding	IDA IDA: Inferred from direct assay	25514493	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	25514493	GOA
enables nuclear androgen receptor binding	IDA IDA: Inferred from direct assay	20812024	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	20812024	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15917220	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription corepressor binding	IDA IDA: Inferred from direct assay	20812024	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	20812024	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	26816381	GOA
involved in erythrocyte maturation	IMP IMP: Inferred from mutant phenotype	26816381	GOA
involved in fat cell differentiation	IMP IMP: Inferred from mutant phenotype	14701838	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12004059	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20812024	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20812024	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20812024	GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25514493	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	15917220	GOA
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	15917220	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	24514149	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	24514149	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	26455326	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14701838	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26455326	GOA
involved in regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	12004059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15917220	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15917220	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB7A Protein Structure

BTB

zf-H2C2_2

0
100
200
300
400
500
584 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 7A

HIV-1 1st-binding protein 1

ZBTB7A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB7A	O95365	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Prey Pooling	25416956
Intra	ZBTB7A	O95365	CHD8	Homo sapiens	Q9HCK8	Anti Tag CoIP	26816381
Intra	ZBTB7A	O95365	CHD8	Homo sapiens	Q9HCK8	Y2H	26816381
Intra	ZBTB7A	O95365	KHDRBS1	Homo sapiens	Q07666	Pull Down	24514149
Intra	ZBTB7A	O95365	KHDRBS1	Homo sapiens	Q07666	Density Sedimentation	24514149
Intra	ZBTB7A	O95365	KHDRBS1	Homo sapiens	Q07666	Anti Tag CoIP	24514149
Intra	ZBTB7A	O95365	KHDRBS1	Homo sapiens	Q07666	Y2H	24514149
Intra	ZBTB7A	O95365	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	26816381
Intra	ZBTB7A	O95365	CHD3	Homo sapiens	Q12873	Anti Tag CoIP	26816381
Intra	ZBTB7A	O95365	CHD3	Homo sapiens	Q12873	Y2H	26816381
Intra	ZBTB7A	O95365	GATAD2B	Homo sapiens	Q8WXI9	Anti Bait CoIP	26816381
Intra	ZBTB7A	O95365	GATAD2B	Homo sapiens	Q8WXI9	Anti Tag CoIP	26816381
Intra	ZBTB7A	O95365	GATAD2B	Homo sapiens	Q8WXI9	Y2H	26816381
Intra	ZBTB7A	O95365	BAZ1A	Homo sapiens	Q9NRL2	Y2H	26816381
Intra	ZBTB7A	O95365	BAZ1A	Homo sapiens	Q9NRL2	Anti Tag CoIP	26816381

Cross: Cross-species interaction Intra: Intraspecies interaction

ZBTB7A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82756	ZBTB7A Antibody (YA2501)	WB, IHC-P, ICC/IF, IP	Human

Related Diseases

Diseases

Alias

Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin

MNDLFH

Photosensitive Epilepsy

Pse	Photogenic Epilepsy
Photoparoxysmal Response	Reflex Epilepsy, Photosensitive
Photoparoxysmal Response 1

Endometrial Mixed Adenocarcinoma

Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin	Delta-Beta-Thalassemia
Delta-Beta Thalassemia	Delta Beta-Thalassemia
HBFQTL1	Hemoglobin F, Hereditary Persistence Of
Hpfh	Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related
Hemoglobin, Fetal, Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Thalassemia
Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]	Fetal Haemoglobin
Persistence Of Fetal Haemoglobin	Persistent Haemoglobin F

Hemoglobinopathy

Hemoglobinopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152775	RK-701	Inhibitor	98.04%	Unkown
HY-RS15979	ZBTB7A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZBTB7A	MGD	MGI:1335091
Rattus norvegicus	ZBTB7A	RGD	RGD:620946
Canis familiaris	ZBTB7A	VGNC	VGNC:48544
Bos taurus	ZBTB7A	VGNC	VGNC:37089
Others	ZBTB7A	NCBI

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