2. Gene
  3. ZMYND10 - zinc finger MYND-type containing 10 Gene

ZMYND10 - zinc finger MYND-type containing 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BLU; FLU; CILD22; DNAAF7

Gene ID: 51364 | Gene type: protein coding

About ZMYND10

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,341,112-50,345,732 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 3 phenotypes. Restricted expression toward testis (RPKM 91.8).

Summary

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in Cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

ZMYND10 Products(2)

mRNA Protein Name
NM_001308379.2 NP_001295308.1 zinc finger MYND domain-containing protein 10 isoform 2
NM_015896.4 NP_056980.2 zinc finger MYND domain-containing protein 10 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in inner dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
involved in motile cilium assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
involved in outer dynein arm assembly IMP
IMP: Inferred from mutant phenotype
23891469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMYND10 Protein Structure

zf-MYND

zf-MYND: MYND finger (394 - 430)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
Protein Preferred Names Protein Names

zinc finger MYND domain-containing protein 10

Ciliary dyskinesia, primary, 22

ZMYND10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra
ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
Intra
ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Array
32296183
Intra
ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Validated Y2H
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Validated Y2H
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Array
32296183
Intra
ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
Intra
ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Array
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Validated Y2H
32296183
Intra
ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Array
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 TBX5 Homo sapiens Q99593
Validated Y2H
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Validated Y2H
32296183
Intra
ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra
ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Validated Y2H
32296183
Intra
ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Array
32296183
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Pooling
16189514
Intra
ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Pull Down
16189514
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Prey Pooling
32296183
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Validated Y2H
32296183
Intra
ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 22

Primary Ciliary Dyskinesia 22

CILD22

Primary Ciliary Dyskinesia 22 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 22, With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, 22
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Kartagener Syndrome

Kartagener'S Syndrome
Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Acute Endometritis
Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy

Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome

SMDCRD

Smd-Crd

Dysplasia, Spondylometaphyseal, With Cone-Rod Dystrophy
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16093 ZMYND10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZMYND10 RGD RGD:1303250
Canis familiaris ZMYND10 VGNC VGNC:48650
Felis catus ZMYND10 VGNC VGNC:67263
Mus musculus ZMYND10 MGD MGI:2387863
Bos taurus ZMYND10 VGNC VGNC:37201
Macaca mulatta ZMYND10 VGNC VGNC:79195