RBM11 - RNA binding motif protein 11 Gene

Homo sapiens

Gene ID: 54033 | Gene type: protein coding

About RBM11

Cytogenetic location: 21q11.2 Genomic coordinates (GRCh38): 21:14,216,157-14,228,372 (from NCBI)

This gene has 6 transcripts (splice variants), 135 orthologues and 1 paralogue. Broad expression in ovary (RPKM 1.3), thyroid (RPKM 1.3) and 21 other tissues.

Summary

Enables poly(U) RNA binding activity and protein homodimerization activity. Acts upstream of or within cellular response to oxidative stress and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

RBM11 Products(2)

mRNA	Protein	Name
NM_001320602.2	NP_001307531.1	splicing regulator RBM11 isoform 2
NM_144770.5	NP_658983.3	splicing regulator RBM11 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	21984414	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21984414	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to oxidative stress	IDA IDA: Inferred from direct assay	21984414	GOA
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	21984414	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	21984414	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	21984414	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21984414	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM11 Protein Structure

RRM_1

0
100
200
281 a.a.

Protein Preferred Names

Protein Names

splicing regulator RBM11

putative RNA-binding protein 11

RBM11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBM11	P57052	ZFHX3	Homo sapiens	Q15911-2	Validated Y2H	32296183
Intra	RBM11	P57052	SNRPC	Homo sapiens	Q5TAL4	Validated Y2H	25416956
Intra	RBM11	P57052	SNRPC	Homo sapiens	Q5TAL4	Y2H Prey Pooling	25416956
Intra	RBM11	P57052	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	RBM11	P57052	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	RBM11	P57052	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	RBM11	P57052	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	RBM11	P57052	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	RBM11	P57052	ZCCHC8	Homo sapiens	Q6NZY4	Anti Tag CoIP	28514442
Intra	RBM11	P57052	ZCCHC8	Homo sapiens	Q6NZY4	Y2H Fragment Pooling	35914814
Intra	RBM11	P57052	ZCCHC8	Homo sapiens	Q6NZY4	Anti Tag CoIP	33961781
Intra	RBM11	P57052	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	RBM11	P57052	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	RBM11	P57052	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RBM11	P57052	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RBM11	P57052	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RBM11	P57052	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	RBM11	P57052	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	RBM11	P57052	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	RBM11	P57052	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	RBM11	P57052	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	RBM11	P57052	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	RBM11	P57052	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	RBM11	P57052	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	RBM11	P57052	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	RBM11	P57052	ZNF414	Homo sapiens	Q96IQ9	Validated Y2H	32296183
Intra	RBM11	P57052	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	RBM11	P57052	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	RBM11	P57052	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	RBM11	P57052	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	RBM11	P57052	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	RBM11	P57052	QKI	Homo sapiens	Q96PU8	Y2H Array	25416956
Intra	RBM11	P57052	FLNA	Homo sapiens	P21333-2	Y2H Pooling	32814053
Intra	RBM11	P57052	FLNA	Homo sapiens	P21333-2	Validated Y2H	32814053
Intra	RBM11	P57052	FLNA	Homo sapiens	P21333-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11732	RBM11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RBM11	VGNC	VGNC:76681
Rattus norvegicus	RBM11	RGD	RGD:1305195
Canis familiaris	RBM11	VGNC	VGNC:45405
Mus musculus	RBM11	MGD	MGI:2447622
Felis catus	RBM11	VGNC	VGNC:69263
Bos taurus	RBM11	VGNC	VGNC:33784

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