SNX7 - sorting nexin 7 Gene

Homo sapiens

Gene ID: 51375 | Gene type: protein coding

About SNX7

Cytogenetic location: 1p21.3 Genomic coordinates (GRCh38): 1:98,661,319-98,760,500 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 15 paralogues. Ubiquitous expression in colon (RPKM 10.6), small intestine (RPKM 8.3) and 24 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region like some family members, and its exact function is unknown. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jun 2010]

SNX7 Products(3)

mRNA	Protein	Name
NM_001364903.1	NP_001351832.1	sorting nexin-7 isoform c
NM_015976.5	NP_057060.2	sorting nexin-7 isoform a
NM_152238.4	NP_689424.2	sorting nexin-7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	32513819	GOA
involved in protein transport	IMP IMP: Inferred from mutant phenotype	32513819	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in early endosome	IDA IDA: Inferred from direct assay	32513819	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX7 Protein Structure

0
100
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300
400
451 a.a.

Protein Preferred Names

Protein Names

sorting nexin-7

SNX7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNX7	Q9UNH6	SNX4	Homo sapiens	O95219	Anti Tag CoIP	35271311
Intra	SNX7	Q9UNH6	SNX4	Homo sapiens	O95219	Pull Down	23085988
Intra	SNX7	Q9UNH6	SNX4	Homo sapiens	O95219	Anti Tag CoIP	33961781
Intra	SNX7	Q9UNH6	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	SNX7	Q9UNH6	TEX11	Homo sapiens	Q8IYF3	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153596	SNX7		99.89%	Unkown
HY-RS13546	SNX7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SNX7	VGNC	VGNC:80362
Rattus norvegicus	SNX7	RGD	RGD:1305480
Canis familiaris	SNX7	VGNC	VGNC:46643
Bos taurus	SNX7	VGNC	VGNC:35113
Mus musculus	SNX7	MGD	MGI:1923811
Macaca mulatta	SNX7	VGNC	VGNC:106500

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