NIP7 - nucleolar pre-rRNA processing protein NIP7 Gene

Homo sapiens

Also known as KD93; CGI-37; HSPC031

Gene ID: 51388 | Gene type: protein coding

About NIP7

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,339,772-69,343,106 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 9.5), appendix (RPKM 8.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NIP7 Products(2)

mRNA	Protein	Name
NM_001199434.2	NP_001186363.1	60S ribosome subunit biogenesis protein NIP7 homolog isoform 2
NM_016101.5	NP_057185.1	60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14660641	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NIP7 Protein Structure

UPF0113

0
100
180 a.a.

Protein Preferred Names

Protein Names

60S ribosome subunit biogenesis protein NIP7 homolog

NIP7, nucleolar pre-rRNA processing protein

Recombinant NIP7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71162	NIP7 Protein, Human (His)	Q9Y221-1 (M1-T180)	≥95%

Related Diseases

Diseases

Alias

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09301	NIP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NIP7	VGNC	VGNC:32080
Mus musculus	NIP7	MGD	MGI:1913414
Felis catus	NIP7	VGNC	VGNC:63806
Canis familiaris	NIP7	VGNC	VGNC:43814
Rattus norvegicus	NIP7	RGD	RGD:620069
Macaca mulatta	NIP7	VGNC	VGNC:99527
Others	NIP7	NCBI

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