2. Gene
  3. MAGEC2 - MAGE family member C2 Gene

MAGEC2 - MAGE family member C2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CT10; HCA587; MAGEE1

Gene ID: 51438 | Gene type: protein coding

About MAGEC2

Cytogenetic location: Xq27.2 Genomic coordinates (GRCh38): X:142,202,342-142,205,290 (from NCBI)

This gene has 1 transcript (splice variant), 463 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 15.6).

Summary

This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the Other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]

MAGEC2 Products(1)

mRNA Protein Name
NM_016249.4 NP_057333.1 melanoma-associated antigen C2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20864041 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
20864041 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
20864041 GOA
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
20864041 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEC2 Protein Structure

MAGE_N

MAGE_N: Melanoma associated antigen family N terminal (68 - 126)

MAGE

MAGE: MAGE family (148 - 314)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

melanoma-associated antigen C2

MAGE-C2 antigen

MAGEC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAGEC2 Q9UBF1 P4HA3 Homo sapiens Q7Z4N8
Validated Y2H
25416956
Intra
MAGEC2 Q9UBF1 P4HA3 Homo sapiens Q7Z4N8
Y2H Array
31515488
Intra
MAGEC2 Q9UBF1 SSX1 Homo sapiens Q16384
Y2H Prey Pooling
25416956
Intra
MAGEC2 Q9UBF1 SSX1 Homo sapiens Q16384
Y2H Array
25416956
Intra
MAGEC2 Q9UBF1 PBX3 Homo sapiens Q5JS98
Y2H Prey Pooling
25416956
Intra
MAGEC2 Q9UBF1 PBX3 Homo sapiens Q5JS98
Validated Y2H
25416956
Intra
MAGEC2 Q9UBF1 PBX3 Homo sapiens Q5JS98
Y2H Array
25416956
Intra
MAGEC2 Q9UBF1 YARS1 Homo sapiens P54577
Validated Y2H
32814053
Intra
MAGEC2 Q9UBF1 YARS1 Homo sapiens P54577
Y2H Array
32814053
Intra
MAGEC2 Q9UBF1 YARS1 Homo sapiens P54577
Y2H Pooling
32814053
Intra
MAGEC2 Q9UBF1 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
MAGEC2 Q9UBF1 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
MAGEC2 Q9UBF1 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
MAGEC2 Q9UBF1 UBE2H Homo sapiens P62256
Pull Down
20864041
Intra
MAGEC2 Q9UBF1 SSX2 Homo sapiens Q16385
Y2H Array
25416956
Intra
MAGEC2 Q9UBF1 SSX2 Homo sapiens Q16385
Y2H Prey Pooling
25416956
Intra
MAGEC2 Q9UBF1 SSX2 Homo sapiens Q16385
Validated Y2H
25416956
Intra
MAGEC2 Q9UBF1 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
MAGEC2 Q9UBF1 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
MAGEC2 Q9UBF1 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
MAGEC2 Q9UBF1 TRIM28 Homo sapiens Q13263
Pull Down
20864041
Intra
MAGEC2 Q9UBF1 TRIM28 Homo sapiens Q13263
Y2H
21277283
Intra
MAGEC2 Q9UBF1 TRIM28 Homo sapiens Q13263
TAP
20864041
Cross: Cross-species interaction Intra: Intraspecies interaction

MAGEC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81369 MAGEC2 Antibody (YA1114) IHC-P Human

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Malignant Anus Melanoma

Anal Melanoma

Malignant Melanoma Of Anus
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07974 MAGEC2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAGEC2 RGD RGD:1563272
Mus musculus MAGEC2 MGD MGI:1921687