SSX2 - SSX family member 2 Gene

Homo sapiens

Also known as SSX; HD21; CT5.2; CT5.2A; HOM-MEL-40

Gene ID: 6757 | Gene type: protein coding

About SSX2

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:52,696,896-52,707,227 (from NCBI)

This gene has 3 transcripts (splice variants), 101 orthologues, 7 paralogues and is associated with 28 phenotypes. Restricted expression toward testis (RPKM 18.4).

Summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in Cancer patients, and are potentially useful targets in Cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]

SSX2 Products(3)

mRNA	Protein	Name
NM_001278697.2	NP_001265626.1	protein SSX2 isoform c
NM_003147.6	NP_003138.3	protein SSX2 isoform a
NM_175698.4	NP_783629.1	protein SSX2 isoform b

SSX2 Protein Structure

KRAB

SSXRD

0
100
188 a.a.

Protein Preferred Names

Protein Names

protein SSX2

cancer/testis antigen 5.2

Related Diseases

Diseases

Alias

Sarcoma, Synovial

Synovial Sarcoma	Synovialosarcoma
Synovial Cell Sarcoma	Sarcoma Synovial

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Lung Sarcoma

Pulmonary Sarcoma

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Seminoma

Seminoma, Pure

Malignant Glandular Tumor Of Peripheral Nerve Sheath

Glandular Mpnst

Glandular Malignant Peripheral Nerve Sheath Tumor

Spindle Cell Synovial Sarcoma

Synovial Sarcoma With Spindle Cell Components	Synovial Sarcoma, Monophasic Fibrous
Synovial Sarcoma, Spindle Cell

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Sarcomatoid Renal Cell Carcinoma

Renal Cell Carcinoma, Spindle Cell

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Liver Fibroma

Fibroma Of The Liver

Liver Solitary Fibrous Tumor

Kidney Hemangiopericytoma

Hemangiopericytoma Of Kidney

Renal Hemangiopericytoma

Cellular Neurofibroma

Spindle Cell Thymoma

Medullary Thymoma	Thymoma, Medullary
Thymoma, Type A

Kidney Sarcoma

Renal Sarcoma

Sarcoma Of Kidney

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Heart Sarcoma

Cardiac Sarcoma

Sarcoma Of Heart

Spindle Cell Sarcoma

Sarcoma	Sarcoma Spindle Cell
Sarcoma, Spindle Cell	Sarcoma - Category

Epithelioid Malignant Peripheral Nerve Sheath Tumor

Epithelioid Mpnst

Malignant Epithelioid Neoplasm Of The Peripheral Nerve Sheath

Malignant Mesenchymoma

Malignant Mesenchymal Tumor	Mesenchymoma, Malignant
Sarcoma	Rat Malignant Renal Mesenchymal Tumor

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Sarcomatoid Mesothelioma

Malignant Fibrous Mesothelioma

Spindled Mesothelioma

Spermatic Cord Cancer

Malignant Tumor Of Spermatic Cord	Malignant Tumor Of The Spermatic Cord
Spermatic Cord Ca	Malignant Neoplasm Of Spermatic Cord

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Desmoplastic Small Round Cell Tumor

Dsrct	Desmoplastic Small Round-Cell Tumor
Desmoplastic Small Round-Cell Neoplasm

Hemangiopericytoma, Malignant

Hemangiopericytoma	Haemangiopericytic Meningioma
Malignant Hemangiopericytoma	Solitary Fibrous Tumor

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Meninges Sarcoma

Meningeal Sarcoma	Sarcoma Of Meninges
Meningothelial Sarcoma	Leptomeningeal Sarcoma

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Spermatocytoma

Spermatocytic Seminoma

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Muscle Cancer

Myosarcoma	Malignant Neoplasm Of Muscle
Malignant Tumor Of Muscle	Malignant Tumor Of The Muscle
Muscle Neoplasms	Myomatous Neoplasm

Ovarian Angiosarcoma

Hemangiosarcoma Of Ovary

Clear Cell Sarcoma

Sarcoma, Clear Cell	Adult Soft Part Clear Cell Sarcoma
Clear Cell Sarcoma Of Soft Parts	Malignant Melanoma Of Soft Parts
Malignant Melanoma Of Soft Tissues	Melanoma, Malignant, Of Soft Parts
Sarcoma Clear Cell

Myxoid Chondrosarcoma

Synovium Neoplasm

Synovial Neoplasm

Tumor Of Synovium

Cellular Myxoid Liposarcoma

Round Cell Liposarcoma

Perivascular Tumor

Malignant Perivascular Cancer

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Alveolar Soft Part Sarcoma

ASPS	Alveolar Soft-Part Sarcoma
Sarcoma, Alveolar Soft Part	Alveolar Soft Tissue Sarcoma
Sarcoma Alveolar Soft Part	Adult Alveolar Soft-Part Sarcoma
Childhood Alveolar Soft-Part Sarcoma

Epithelioid Sarcoma

Epithelioid Cell Sarcoma	Sarcoma Epithelioid
Sarcoma, Epithelioid

Mesenchymal Cell Neoplasm

Benign Miscellaneous Mesenchymal Tumor	Mesenchymal Tumor
Mesenchymal Tumors

Rhabdomyosarcoma

Pyriform Sinus Cancer

Malignant Neoplasm Of Pyriform Fossa	Malignant Neoplasm Of The Pyriform Fossa
Malignant Tumor Of Pyriform Fossa

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Kidney Cortex Disease

Rhabdoid Cancer

Rhabdoid Tumor	Malignant Rhabdoid Tumor
Malignant Rhabdoid Tumour	Rhabdoid Sarcoma
Rhabdoid Tumor Predisposition Syndrome 1	Rhabdoid Tumor Predisposition Syndrome 2
Atypical Teratoid Rhabdoid Tumor	Brain Tumor, Posterior Fossa, Of Infancy, Familial
Atypical Teratoid/Rhabdoid Tumor

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma	Rhabdomyosarcoma, Alveolar
Rhabdomyosarcoma Alveolar	RMS2
Rmsa	Rhabdomyosarcoma 2, Alveolar
Alveolar Childhood Rhabdomyosarcoma	Arms
Rhabdomyosarcoma, Type 2

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Congenital Mesoblastic Nephroma

Mesoblastic Nephroma

Nephroma, Mesoblastic

Thymus Sarcomatoid Carcinoma

Thymic Carcinosarcoma

Thymic Sarcomatoid Carcinoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal	Rhabdomyosarcoma Embryonal
Botryoid Rhabdomyosarcoma	Erms
Spindle Cell Rhabdomyosarcomas

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Endometrial Stromal Sarcoma

Ess	Endometrial Stromal Sarcoma, High Grade
Undifferentiated Endometrial Sarcoma	Stromal Sarcoma Of The Corpus Uteri
Sarcoma Endometrial Stromal	Sarcoma, Endometrial Stromal
Undifferentiated Stromal Sarcoma

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13837	SSX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13838	SSX2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown