NUDT16L1 - nudix hydrolase 16 like 1 Gene

Homo sapiens

Also known as SDOS; TIRR

Gene ID: 84309 | Gene type: protein coding

About NUDT16L1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,693,562-4,695,859 (from NCBI)

This gene has 5 transcripts (splice variants), 172 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 5.2), prostate (RPKM 4.4) and 25 other tissues.

Summary

Enables snoRNA binding activity. Involved in negative regulation of double-strand break repair via nonhomologous end joining. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NUDT16L1 Products(6)

mRNA	Protein	Name
NM_001193452.1	NP_001180381.1	tudor-interacting repair regulator protein isoform 2
NM_001370585.1	NP_001357514.1	tudor-interacting repair regulator protein isoform 3
NM_001370586.1	NP_001357515.1	tudor-interacting repair regulator protein isoform 4
NM_001370587.1	NP_001357516.1	tudor-interacting repair regulator protein isoform 5
NM_001370588.1	NP_001357517.1	tudor-interacting repair regulator protein isoform 6
NM_032349.4	NP_115725.1	tudor-interacting repair regulator protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	IDA IDA: Inferred from direct assay	18820299	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
NOT enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18820299	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	18820299	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	28241136	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	28241136	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tudor-interacting repair regulator protein

NUDT16-like protein 1

NUDT16L1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUDT16L1	Q9BRJ7	METTL17	Homo sapiens	Q9H7H0-2	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	CABP2	Homo sapiens	Q9NPB3	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	HNRNPH1	Homo sapiens	P31943	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	HNRNPH1	Homo sapiens	P31943	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	NUDT16L1	Q9BRJ7	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	NUDT16L1	Q9BRJ7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	NUDT16L1	Q9BRJ7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Testicular Yolk Sac Tumor

Testicular Yolk Sac Neoplasm	Endodermal-Sinus Tumor
Orchidoblastoma	Yolk Sac Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09667	NUDT16L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NUDT16L1	VGNC	VGNC:75474
Bos taurus	NUDT16L1	VGNC	VGNC:32331
Mus musculus	NUDT16L1	MGD	MGI:1914161
Canis familiaris	NUDT16L1	VGNC	VGNC:44029
Rattus norvegicus	NUDT16L1	RGD	RGD:1561451

Name
Email *

	Sorry, but the email address you supplied was invalid.