ISYNA1 - inositol-3-phosphate synthase 1 Gene

Homo sapiens

Also known as IPS; INO1; INOS; IPS 1; IPS-1

Gene ID: 51477 | Gene type: protein coding

About ISYNA1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,434,388-18,438,133 (from NCBI)

This gene has 14 transcripts (splice variants) and 208 orthologues. Broad expression in testis (RPKM 72.6), placenta (RPKM 57.0) and 14 other tissues.

Summary

This gene encodes an inositol-3-phosphate synthase Enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

ISYNA1 Products(3)

mRNA	Protein	Name
NM_001170938.2	NP_001164409.1	inositol-3-phosphate synthase 1 isoform 2
NM_001253389.2	NP_001240318.1	inositol-3-phosphate synthase 1 isoform 4
NM_016368.5	NP_057452.1	inositol-3-phosphate synthase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol-3-phosphate synthase activity	IGI IGI: Inferred from genetic interaction	23902760	GOA
enables inositol-3-phosphate synthase activity	IMP IMP: Inferred from mutant phenotype	23902760	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in inositol biosynthetic process	IGI IGI: Inferred from genetic interaction	23902760	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISYNA1 Protein Structure

NAD_binding_5

Inos-1-P_synth

0
100
200
300
400
500
558 a.a.

Protein Preferred Names

Protein Names

inositol-3-phosphate synthase 1

MI-1-P synthase

ISYNA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ISYNA1	Q9NPH2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Bait-Prey Pool	25910212
Intra	ISYNA1	Q9NPH2	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25910212
Intra	ISYNA1	Q9NPH2	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25910212
Intra	ISYNA1	Q9NPH2	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	ISYNA1	Q9NPH2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	ISYNA1	Q9NPH2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	ISYNA1	Q9NPH2	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lidocaine Allergy

Lidoderm Allergy	Lignocaine Allergy
Xylocaine Allergy

Nemaline Myopathy 1

Cap Myopathy 1	NEM1
Nemaline Myopathy 1, Autosomal Dominant Or Recessive	Nemaline Myopathy, Type 1
CAPM1	Cap Disease
Cap Myopathy Tpm3-Related	Nemaline Myopathy 1 Autosomal Dominant Or Recessive
Myopathy, Nemaline, Type 1	Cap Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06942	ISYNA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ISYNA1	VGNC	VGNC:73685
Bos taurus	ISYNA1	VGNC	VGNC:30306
Canis familiaris	ISYNA1	VGNC	VGNC:42116
Mus musculus	ISYNA1	MGD	MGI:1919030
Rattus norvegicus	ISYNA1	RGD	RGD:1359423
Felis catus	ISYNA1	VGNC	VGNC:62982

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