CWC15 - CWC15 spliceosome associated protein homolog Gene

Homo sapiens

Also known as ORF5; AD002; Cwf15; C11orf5; HSPC148

Gene ID: 51503 | Gene type: protein coding

About CWC15

This gene has 6 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 28.4), bone marrow (RPKM 17.4) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in mitochondrion and nuclear speck. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

CWC15 Products(3)

mRNA	Protein	Name
NM_001363371.2	NP_001350300.1	spliceosome-associated protein CWC15 homolog
NM_001363372.2	NP_001350301.1	spliceosome-associated protein CWC15 homolog
NM_016403.4	NP_057487.2	spliceosome-associated protein CWC15 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20176811	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Prp19 complex	IPI IPI: Inferred from physical interaction	20176811	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20176811	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	20176811	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	20176811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CWC15 Protein Structure

Cwf_Cwc_15

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

spliceosome-associated protein CWC15 homolog

CWC15 spliceosome-associated protein

CWC15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CWC15	Q9P013	CTNNBL1	Homo sapiens	Q8WYA6	Y2H	22365833
Intra	CWC15	Q9P013	CTNNBL1	Homo sapiens	Q8WYA6	Anti Tag CoIP	20176811
Intra	CWC15	Q9P013	CTNNBL1	Homo sapiens	Q8WYA6	Far-WB	20176811
Intra	CWC15	Q9P013	CTNNBL1	Homo sapiens	Q8WYA6	Pull Down	20176811
Intra	CWC15	Q9P013	CTNNBL1	Homo sapiens	Q8WYA6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Actinobacillosis

Noonan Syndrome 12

NS12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03372	CWC15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CWC15	VGNC	VGNC:56100
Rattus norvegicus	CWC15	RGD	RGD:1310669
Felis catus	CWC15	VGNC	VGNC:82006
Macaca mulatta	CWC15	VGNC	VGNC:100916
Bos taurus	CWC15	VGNC	VGNC:54863
Mus musculus	CWC15	MGD	MGI:1913320

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