TRMT112 - tRNA methyltransferase activator subunit 11-2 Gene

Homo sapiens

Also known as TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2

Gene ID: 51504 | Gene type: protein coding

About TRMT112

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,316,460-64,318,596 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues.

Summary

Enables protein heterodimerization activity and protein methyltransferase activity. Involved in macromolecule methylation and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

TRMT112 Products(5)

mRNA	Protein	Name
NM_001286082.2	NP_001273011.1	multifunctional methyltransferase subunit TRM112-like protein isoform 2
NM_001286084.2	NP_001273013.1	multifunctional methyltransferase subunit TRM112-like protein isoform 3
NM_001372071.1	NP_001359000.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_001372072.1	NP_001359001.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1
NM_016404.3	NP_057488.1	multifunctional methyltransferase subunit TRM112-like protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18539146	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	25851604	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	18539146	GOA
enables tRNA methyltransferase activator activity	IDA IDA: Inferred from direct assay	34669960	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-glutamine methylation	IDA IDA: Inferred from direct assay	18539146	GOA
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in rRNA (guanine-N7)-methylation	IMP IMP: Inferred from mutant phenotype	25851604	GOA
involved in rRNA methylation	IDA IDA: Inferred from direct assay	31328227	GOA
involved in tRNA methylation	IMP IMP: Inferred from mutant phenotype	34669960	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	31061526	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	25851604	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25851604	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	18539146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT112 Protein Structure

Trm112p

0
100
125 a.a.

Protein Preferred Names

Protein Names

multifunctional methyltransferase subunit TRM112-like protein

TRM112-like protein

Recombinant TRMT112 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71644	TRMT112 Protein, Human (His-SUMO)	Q9UI30-1 (M1-S125)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Restrictive, 1

RCM1	Restrictive Cardiomyopathy 1
Rcm	Familial Restrictive Cardiomyopathy 1
Cardiomyopathy, Familial Restrictive 1	Cardiomyopathy, Restrictive, Familial, Type 1
Rcm-1

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15090	TRMT112 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRMT112	VGNC	VGNC:101420
Canis familiaris	TRMT112	VGNC	VGNC:47855
Felis catus	TRMT112	VGNC	VGNC:81099
Mus musculus	TRMT112	MGD	MGI:1914924
Rattus norvegicus	TRMT112	RGD	RGD:1309710
Others	TRMT112	NCBI

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