CHMP5 - charged multivesicular body protein 5 Gene

Homo sapiens

Also known as Vps60; CGI-34; PNAS-2; C9orf83; HSPC177; SNF7DC2

Gene ID: 51510 | Gene type: protein coding

About CHMP5

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,265,049-33,282,070 (from NCBI)

This gene has 3 transcripts (splice variants), 290 orthologues and 4 paralogues. Ubiquitous expression in colon (RPKM 33.4), thyroid (RPKM 32.0) and 25 other tissues.

Summary

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP5 Products(2)

mRNA	Protein	Name
NM_001195536.2	NP_001182465.1	charged multivesicular body protein 5 isoform 2
NM_016410.6	NP_057494.3	charged multivesicular body protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15644320	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27812135	GOA
involved in cellular response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	27812135	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	15644320	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040713	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding	IMP IMP: Inferred from mutant phenotype	15644320	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in cytosol	IDA IDA: Inferred from direct assay	15644320	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP5 Protein Structure

Snf7

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

charged multivesicular body protein 5

SNF7 domain containing 2

CHMP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHMP5	Q9NZZ3	VPS4B	Homo sapiens	O75351	Y2H Array	25416956
Intra	CHMP5	Q9NZZ3	VPS4B	Homo sapiens	O75351	Y2H Prey Pooling	25416956
Intra	CHMP5	Q9NZZ3	MITD1	Homo sapiens	Q8WV92	Validated Y2H	25416956
Intra	CHMP5	Q9NZZ3	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	17711858
Intra	CHMP5	Q9NZZ3	VTA1	Homo sapiens	Q9NP79	Anti Tag CoIP	28514442
Intra	CHMP5	Q9NZZ3	VTA1	Homo sapiens	Q9NP79	Anti Tag CoIP	33961781
Intra	CHMP5	Q9NZZ3	CHMP4B	Homo sapiens	Q9H444	Y2H	16730941

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7

Ftd3	Frontotemporal Dementia, Chromosome 3-Linked
Amyotrophic Lateral Sclerosis, Chmp2b-Related	Chromosome 3-Linked Frontotemporal Dementia
FTDALS7	Chmp2b-Related Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 17, Formerly	Als17, Formerly
Amyotrophic Lateral Sclerosis Type 17	Dtm1
Ftd-3	Ftd-Chmp2b
Als17	Amyotrophic Lateral Sclerosis 17
Sclerosis, Lateral, Amyotrophic, Type 17	Dementia, Frontotemporal, Chromosome 3-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02646	CHMP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CHMP5	VGNC	VGNC:103666
Macaca mulatta	CHMP5	VGNC	VGNC:103250
Felis catus	CHMP5	VGNC	VGNC:60865
Mus musculus	CHMP5	MGD	MGI:1924209
Rattus norvegicus	CHMP5	RGD	RGD:1305968
Bos taurus	CHMP5	VGNC	VGNC:27304

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