STAMBP - STAM binding protein Gene

Homo sapiens

Also known as AMSH; MICCAP

Gene ID: 10617 | Gene type: protein coding

About STAMBP

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,828,961-73,873,656 (from NCBI)

This gene has 71 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues.

Summary

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

STAMBP Products(13)

mRNA	Protein	Name
NM_001353967.2	NP_001340896.1	STAM-binding protein isoform 1
NM_001353968.2	NP_001340897.1	STAM-binding protein isoform 1
NM_001353969.2	NP_001340898.1	STAM-binding protein isoform 2
NM_001353970.2	NP_001340899.1	STAM-binding protein isoform 2
NM_001353971.2	NP_001340900.1	STAM-binding protein isoform 3
NM_001353972.2	NP_001340901.1	STAM-binding protein isoform 3
NM_001353973.2	NP_001340902.1	STAM-binding protein isoform 3
NM_001353974.2	NP_001340903.1	STAM-binding protein isoform 3
NM_001353975.2	NP_001340904.1	STAM-binding protein isoform 3
NM_001353976.2	NP_001340905.1	STAM-binding protein isoform 4
NM_006463.6	NP_006454.1	STAM-binding protein isoform 1
NM_201647.4	NP_964010.1	STAM-binding protein isoform 1
NM_213622.4	NP_998787.1	STAM-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables K63-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	34425109	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	18388320	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10383417	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18395747	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	18388320	GOA
involved in negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	23542699	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	23542699	GOA
acts upstream of or within protein deubiquitination	IMP IMP: Inferred from mutant phenotype	18388320	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cleavage furrow	IDA IDA: Inferred from direct assay	18388320	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAMBP Protein Structure

USP8_dimer

JAB

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

STAM-binding protein

associated molecule with the SH3 domain of STAM

STAMBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STAMBP	O95630	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	STAMBP	O95630	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	STAMBP	O95630	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	STAMBP	O95630	CHMP1A	Homo sapiens	Q9HD42	Anti Tag CoIP	17711858
Intra	STAMBP	O95630	CHMP1A	Homo sapiens	Q9HD42	Y2H	17711858
Intra	STAMBP	O95630	CHMP1A	Homo sapiens	Q9HD42	Anti Tag CoIP	33961781
Intra	STAMBP	O95630	CHMP1A	Homo sapiens	Q9HD42	Anti Tag CoIP	28514442
Intra	STAMBP	O95630	APOBEC3A	Homo sapiens	P31941	Validated Y2H	32296183
Intra	STAMBP	O95630	BMP2K	Homo sapiens	Q9NSY1	Anti Tag CoIP	33961781
Intra	STAMBP	O95630	BMP2K	Homo sapiens	Q9NSY1	Anti Tag CoIP	28514442
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7-1	Pull Down	21827950
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Y2H	21988832
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Y2H	16730941
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Y2H Prey Pooling	25416956
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Validated Y2H	25416956
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Pull Down	21827950
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	Validated Y2H	32296183
Intra	STAMBP	O95630	CHMP1B	Homo sapiens	Q7LBR1	SPR	21827950
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Anti Tag CoIP	28514442
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Y2H Prey Pooling	25416956
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Y2H	16730941
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Pull Down	17711858
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Anti Tag CoIP	19615732
Intra	STAMBP	O95630	CHMP3	Homo sapiens	Q9Y3E7	Y2H	17711858
Intra	STAMBP	O95630	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	STAMBP	O95630	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	STAMBP	O95630	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	STAMBP	O95630	CHMP2A	Homo sapiens	O43633	Anti Tag CoIP	33961781
Intra	STAMBP	O95630	CHMP2A	Homo sapiens	O43633	Anti Tag CoIP	28514442
Intra	STAMBP	O95630	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	STAMBP	O95630	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	STAMBP	O95630	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	STAMBP	O95630	TRIP13	Homo sapiens	Q15645	Y2H Array	31515488
Intra	STAMBP	O95630	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	STAMBP	O95630	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	STAMBP	O95630	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	STAMBP	O95630	STAM2	Homo sapiens	O75886	Y2H Pooling	19060904
Intra	STAMBP	O95630	STAM2	Homo sapiens	O75886	Y2H Array	19060904
Intra	STAMBP	O95630	RNF11	Homo sapiens	Q9Y3C5	Anti Tag CoIP	14755250
Intra	STAMBP	O95630	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	STAMBP	O95630	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	STAMBP	O95630	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	STAMBP	O95630	RNF11	Homo sapiens	Q9Y3C5	Y2H	14755250
Intra	STAMBP	O95630	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	STAMBP	O95630	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	STAMBP	O95630	GRB2	Homo sapiens	P62993	Anti Tag CoIP	19615732
Intra	STAMBP	O95630	UBB	Homo sapiens	P0CG47	Validated Y2H	32814053
Intra	STAMBP	O95630	UBB	Homo sapiens	P0CG47	Y2H Pooling	32814053
Intra	STAMBP	O95630	UBB	Homo sapiens	P0CG47	Y2H Array	32814053
Intra	STAMBP	O95630	SMAD6	Homo sapiens	O43541-2	Y2H	11483516
Intra	STAMBP	O95630	CHMP5	Homo sapiens	Q9NZZ3	Y2H	21988832
Intra	STAMBP	O95630	STAM	Homo sapiens	Q92783	ITC	17078930
Intra	STAMBP	O95630	STAM	Homo sapiens	Q92783	Anti Tag CoIP	10383417
Intra	STAMBP	O95630	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	STAMBP	O95630	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	STAMBP	O95630	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

STAMBP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82962	AMSH Antibody (YA2707)	WB	Human

Related Diseases

Diseases

Alias

Microcephaly-Capillary Malformation Syndrome

Mic-Cap Syndrome	MICCAP
Mic-Cm Syndrome	Microcephaly-Cutaneous Capillary Malformation Syndrome

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome	Arthropathy-Camptodactyly Syndrome
Pericarditis-Arthropathy-Camptodactyly Syndrome	Xyy Syndrome
Pac Syndrome	Cacp Syndrome
CACP	Fibrosing Serositis, Familial
Camptodactyly-Arthropathy-Pericarditis Syndrome	Cap Syndrome
47, Xyy Syndrome	47,Xyy Syndrome
Double Y Syndrome	Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Hypertrophic Synovitis, Congenital Familial	Congenital Familial Hypertrophic Synovitis
Xyy Karyotype	Y Disomy
Yy Syndrome	Familial Fibrosing Serositis
Disomy Y	Double Y
Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome	Arthropathy Camptodactyly Syndrome
Camptodactyly Arthropathy Pericarditis Syndrome	Pericarditis Arthropathy Camptodactyly Syndrome
Jacob'S Syndrome	47,Xyy
Cdags Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122883	BC-1471	Inhibitor	99.69%	Unkown
HY-141852	STAMBP-IN-1	Inhibitor	98.37%	Unkown
HY-RS13871	STAMBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAMBP	VGNC	VGNC:77935
Rattus norvegicus	STAMBP	RGD	RGD:619963
Mus musculus	STAMBP	MGD	MGI:1917777
Bos taurus	STAMBP	VGNC	VGNC:35356
Felis catus	STAMBP	VGNC	VGNC:65747
Others	STAMBP	NCBI

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