MBIP - MAP3K12 binding inhibitory protein 1 Gene

Homo sapiens

Gene ID: 51562 | Gene type: protein coding

About MBIP

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,298,564-36,320,637 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 34.1), lung (RPKM 32.4) and 24 other tissues.

Summary

Enables identical protein binding activity and protein kinase inhibitor activity. Involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MBIP Products(3)

mRNA	Protein	Name
NM_001144891.2	NP_001138363.1	MAP3K12-binding inhibitory protein 1 isoform 2
NM_001308110.2	NP_001295039.1	MAP3K12-binding inhibitory protein 1 isoform 3
NM_016586.3	NP_057670.2	MAP3K12-binding inhibitory protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	10801814	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	10801814	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	32963352	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

MAP3K12-binding inhibitory protein 1

MAPK upstream kinase-binding inhibitory protein

MBIP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MBIP	Q9NS73	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	MBIP	Q9NS73	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	MBIP	Q9NS73	WDR5	Homo sapiens	P61964	Anti Tag CoIP	33961781
Intra	MBIP	Q9NS73	TXLNB	Homo sapiens	Q8N3L3	Y2H Array	31515488
Intra	MBIP	Q9NS73	KAT14	Homo sapiens	Q9H8E8	Anti Tag CoIP	33961781
Intra	MBIP	Q9NS73	KAT14	Homo sapiens	Q9H8E8	Y2H Pooling	16189514
Intra	MBIP	Q9NS73	SGF29	Homo sapiens	Q96ES7	Anti Tag CoIP	33961781
Intra	MBIP	Q9NS73	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	MBIP	Q9NS73	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	19060904
Intra	MBIP	Q9NS73	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	19060904

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MBIP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70921	MBIP Protein, Human (His)	Q9NS73-1 (M1-P344)	≥95%

Related Diseases

Diseases

Alias

Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08187	MBIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MBIP	MGD	MGI:1918320
Bos taurus	MBIP	VGNC	VGNC:31279
Felis catus	MBIP	VGNC	VGNC:80921
Canis familiaris	MBIP	VGNC	VGNC:43055
Macaca mulatta	MBIP	VGNC	VGNC:74543
Rattus norvegicus	MBIP	RGD	RGD:1306310
Others	MBIP	NCBI

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