WDR5 - WD repeat domain 5 Gene

Homo sapiens

Also known as BIG3; SWD3; BIG-3; CFAP89

Gene ID: 11091 | Gene type: protein coding

About WDR5

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:134,135,199-134,159,968 (from NCBI)

This gene has 3 transcripts (splice variants), 171 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 24.2), skin (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

WDR5 Products(13)

mRNA	Protein	Name
NM_001384409.1	NP_001371338.1	WD repeat-containing protein 5 isoform 1
NM_001384410.1	NP_001371339.1	WD repeat-containing protein 5 isoform 1
NM_001384411.1	NP_001371340.1	WD repeat-containing protein 5 isoform 1
NM_001384412.1	NP_001371341.1	WD repeat-containing protein 5 isoform 1
NM_001384413.1	NP_001371342.1	WD repeat-containing protein 5 isoform 1
NM_001384414.1	NP_001371343.1	WD repeat-containing protein 5 isoform 1
NM_001384415.1	NP_001371344.1	WD repeat-containing protein 5 isoform 1
NM_001384416.1	NP_001371345.1	WD repeat-containing protein 5 isoform 2
NM_001384417.1	NP_001371346.1	WD repeat-containing protein 5 isoform 3
NM_001384418.1	NP_001371347.1	WD repeat-containing protein 5 isoform 4
NM_001384419.1	NP_001371348.1	WD repeat-containing protein 5 isoform 4
NM_017588.3	NP_060058.1	WD repeat-containing protein 5 isoform 1
NM_052821.4	NP_438172.1	WD repeat-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	16600877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12670868	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	19556245	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
part of MLL1 complex	IDA IDA: Inferred from direct assay	15960975	GOA
part of MLL1 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of MLL1/2 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of MLL3/4 complex	IDA IDA: Inferred from direct assay	17500065	GOA
part of MLL3/4 complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of NSL complex	IDA IDA: Inferred from direct assay	20018852	GOA
part of Set1C/COMPASS complex	IDA IDA: Inferred from direct assay	17998332	GOA
part of Set1C/COMPASS complex	IPI IPI: Inferred from physical interaction	23508102	GOA
part of histone acetyltransferase complex	IDA IDA: Inferred from direct assay	20018852	GOA
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	17355966	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17500065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR5 Protein Structure

WD40

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 5

BMP2-induced 3-kb gene protein

WDR5 Protein-protein interaction Information

Type Intra Cross	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR5	P61964	C1orf104	Homo sapiens	A2RRG2	Validated Y2H	25416956
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73-5	Anti Tag CoIP	28514442
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73-5	Validated Y2H	25416956
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73-5	Y2H Array	25416956
Intra	WDR5	P61964	q9h891_human	Homo sapiens	Q9H891	Y2H Prey Pooling	25416956
Intra	WDR5	P61964	KMT2C	Homo sapiens	Q8NEZ4	TAP	27705803
Intra	WDR5	P61964	KMT2C	Homo sapiens	Q8NEZ4	Pull Down	17500065
Intra	WDR5	P61964	KMT2C	Homo sapiens	Q8NEZ4	TAP	24981860
Intra	WDR5	P61964	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	WDR5	P61964	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	CHD8	Homo sapiens	Q9HCK8	Anti Tag CoIP	15960975
Intra	WDR5	P61964	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	WDR5	P61964	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	WDR5	P61964	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	TAP	27705803
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	Anti Tag CoIP	33961781
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	Validated Y2H	32296183
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	Y2H Array	32296183
Intra	WDR5	P61964	ZXDC	Homo sapiens	Q2QGD7	Y2H Array	29892012
Intra	WDR5	P61964	MAVS	Homo sapiens	Q7Z434-1	Anti Bait CoIP	20080758
Intra	WDR5	P61964	MAVS	Homo sapiens	Q7Z434-1	Anti Tag CoIP	20080758
Intra	WDR5	P61964	MAVS	Homo sapiens	Q7Z434-1	TAP	20080758
Intra	WDR5	P61964	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	WDR5	P61964	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	WDR5	P61964	BBC3	Homo sapiens	Q96PG8	Validated Y2H	32296183
Intra	WDR5	P61964	BBC3	Homo sapiens	Q96PG8	Y2H Array	32296183
Intra	WDR5	P61964	BBC3	Homo sapiens	Q96PG8	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	SSX2IP	Homo sapiens	Q9Y2D8	Validated Y2H	25416956
Intra	WDR5	P61964	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	WDR5	P61964	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	WDR5	P61964	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	WDR5	P61964	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Validated Y2H	25416956
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Validated Y2H	32296183
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Y2H Array	32296183
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Y2H Prey Pooling	25416956
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	HSF2	Homo sapiens	Q03933	Y2H Array	31515488
Intra	WDR5	P61964	KANSL2	Homo sapiens	Q9H9L4	TAP	24981860
Intra	WDR5	P61964	KANSL2	Homo sapiens	Q9H9L4	TAP	27705803
Intra	WDR5	P61964	Q03164-PRO_0000390950	Homo sapiens	Q03164-PRO_0000390950	Anti Bait CoIP	20581860
Intra	WDR5	P61964	BOD1L1	Homo sapiens	Q8NFC6	Anti Tag CoIP	28514442
Intra	WDR5	P61964	BOD1L1	Homo sapiens	Q8NFC6	TAP	24981860
Intra	WDR5	P61964	BOD1L1	Homo sapiens	Q8NFC6	TAP	27705803
Intra	WDR5	P61964	BOD1L1	Homo sapiens	Q8NFC6	Anti Tag CoIP	33961781
Intra	WDR5	P61964	ZZZ3	Homo sapiens	Q8IYH5	Anti Tag CoIP	33961781
Intra	WDR5	P61964	ZZZ3	Homo sapiens	Q8IYH5	TAP	24981860
Intra	WDR5	P61964	ZZZ3	Homo sapiens	Q8IYH5	TAP	27705803
Intra	WDR5	P61964	TRAF3	Homo sapiens	Q13114	Anti Bait CoIP	20080758
Intra	WDR5	P61964	TRAF3	Homo sapiens	Q13114	Anti Tag CoIP	20080758
Intra	WDR5	P61964	TRAF6	Homo sapiens	Q9Y4K3	Anti Bait CoIP	20080758
Intra	WDR5	P61964	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	20080758
Intra	WDR5	P61964	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	WDR5	P61964	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	HCFC1	Homo sapiens	P51610	TAP	24981860
Intra	WDR5	P61964	HCFC1	Homo sapiens	P51610	TAP	27705803
Intra	WDR5	P61964	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	12670868
Intra	WDR5	P61964	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	15960975
Intra	WDR5	P61964	ANAPC2	Homo sapiens	Q9UJX6	Validated Y2H	32296183
Intra	WDR5	P61964	MDM4	Homo sapiens	O15151	Y2H Array	32296183
Intra	WDR5	P61964	MDM4	Homo sapiens	O15151	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	FAM199X	Homo sapiens	Q6PEV8	Anti Tag CoIP	33961781
Intra	WDR5	P61964	FAM199X	Homo sapiens	Q6PEV8	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	FAM199X	Homo sapiens	Q6PEV8	Validated Y2H	32296183
Intra	WDR5	P61964	FAM199X	Homo sapiens	Q6PEV8	Y2H Array	32296183
Intra	WDR5	P61964	FAM199X	Homo sapiens	Q6PEV8	TAP	27705803
Intra	WDR5	P61964	KDM6A	Homo sapiens	O15550	Anti Tag CoIP	33961781
Intra	WDR5	P61964	KDM6A	Homo sapiens	O15550	TAP	27705803
Intra	WDR5	P61964	KDM6A	Homo sapiens	O15550	Anti Bait CoIP	24981860
Intra	WDR5	P61964	MARF1	Homo sapiens	Q9Y4F3	Y2H Array	32296183
Intra	WDR5	P61964	MARF1	Homo sapiens	Q9Y4F3	Validated Y2H	32296183
Intra	WDR5	P61964	MARF1	Homo sapiens	Q9Y4F3	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	15960975
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	GMS	18840606
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	Anti Tag CoIP	33961781
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	Solution Sedimentation	19556245
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	Pull Down	15960975
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	TAP	27705803
Intra	WDR5	P61964	KMT2A	Homo sapiens	Q03164	TAP	24981860
Intra	WDR5	P61964	MEN1	Homo sapiens	O00255	TAP	27705803
Intra	WDR5	P61964	MEN1	Homo sapiens	O00255	Anti Tag CoIP	15960975
Intra	WDR5	P61964	MEN1	Homo sapiens	O00255	TAP	24981860
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	TAP	27705803
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	TAP	24981860
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Anti Tag CoIP	15960975
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Anti Bait CoIP	17500065
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Solution Sedimentation	19556245
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Anti Tag CoIP	33961781
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Anti Bait CoIP	17041588
Intra	WDR5	P61964	RBBP5	Homo sapiens	Q15291	Pull Down	17500065
Cross	WDR5	P61964	Bmal1	Mus musculus	Q9WTL8	Y2H	23555304
Intra	WDR5	P61964	NR2E3	Homo sapiens	Q9Y5X4	Validated Y2H	32296183
Intra	WDR5	P61964	NR2E3	Homo sapiens	Q9Y5X4	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	NR2E3	Homo sapiens	Q9Y5X4	Y2H Array	32296183
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	TAP	24981860
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	Anti Tag CoIP	15960975
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	TAP	27705803
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	GMS	24788516
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	Anti Tag CoIP	33961781
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	Anti Tag CoIP	28514442
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	Pull Down	24788516
Intra	WDR5	P61964	KANSL1	Homo sapiens	Q7Z3B3	ITC	24788516
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	Y2H Array	32296183
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	Anti Tag CoIP	33961781
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	TAP	24981860
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	TAP	27705803
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	Y2H Pooling	16189514
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	MBIP	Homo sapiens	Q9NS73	Validated Y2H	32296183
Intra	WDR5	P61964	PAXIP1	Homo sapiens	Q6ZW49	Anti Tag CoIP	33961781
Intra	WDR5	P61964	PAXIP1	Homo sapiens	Q6ZW49	Anti Bait CoIP	17500065
Intra	WDR5	P61964	PAXIP1	Homo sapiens	Q6ZW49	TAP	24981860
Intra	WDR5	P61964	PAXIP1	Homo sapiens	Q6ZW49	TAP	27705803
Intra	WDR5	P61964	PAXIP1	Homo sapiens	Q6ZW49	Anti Tag CoIP	28514442
Intra	WDR5	P61964	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	WDR5	P61964	ZBTB48	Homo sapiens	P10074	Y2H Prey Pooling	32296183
Intra	WDR5	P61964	ZBTB48	Homo sapiens	P10074	Y2H Array	32296183
Intra	WDR5	P61964	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	WDR5	P61964	KMT2B	Homo sapiens	Q9UMN6	TAP	24981860
Intra	WDR5	P61964	KMT2B	Homo sapiens	Q9UMN6	TAP	27705803
Intra	WDR5	P61964	KMT2B	Homo sapiens	Q9UMN6	Anti Tag CoIP	33961781
Intra	WDR5	P61964	KMT2B	Homo sapiens	Q9UMN6	ITC	24788516
Intra	WDR5	P61964	KMT2B	Homo sapiens	Q9UMN6	Anti Tag CoIP	28514442
Intra	WDR5	P61964	NCOA6	Homo sapiens	Q14686	TAP	24981860
Intra	WDR5	P61964	NCOA6	Homo sapiens	Q14686	TAP	27705803
Intra	WDR5	P61964	NCOA6	Homo sapiens	Q14686	Anti Bait CoIP	17021013
Intra	WDR5	P61964	NCOA6	Homo sapiens	Q14686	Anti Tag CoIP	33961781
Intra	WDR5	P61964	NCOA6	Homo sapiens	Q14686	Anti Tag CoIP	28514442
Intra	WDR5	P61964	H3C1	Homo sapiens	P68431	X-Ray Diffraction	16946699
Intra	WDR5	P61964	H3C1	Homo sapiens	P68431	FPS	16946699
Intra	WDR5	P61964	H3C1	Homo sapiens	P68431	ITC	24788516
Intra	WDR5	P61964	H3C1	Homo sapiens	P68431	ITC	16946699
Intra	WDR5	P61964	ATN1	Homo sapiens	P54259	Y2H Array	16713569
Intra	WDR5	P61964	ATN1	Homo sapiens	P54259	TAP	24981860
Intra	WDR5	P61964	ATN1	Homo sapiens	P54259	TAP	27705803
Intra	WDR5	P61964	ATN1	Homo sapiens	P54259	Anti Tag CoIP	33961781
Intra	WDR5	P61964	ATN1	Homo sapiens	P54259	Anti Tag CoIP	28514442
Intra	WDR5	P61964	KAT6A	Homo sapiens	Q92794	Anti Tag CoIP	20581860
Intra	WDR5	P61964	KAT6A	Homo sapiens	Q92794	Confocal	20581860
Intra	WDR5	P61964	KAT6A	Homo sapiens	Q92794	Anti Bait CoIP	20581860
Intra	WDR5	P61964	KMT2D	Homo sapiens	O14686	TAP	27705803
Intra	WDR5	P61964	KMT2D	Homo sapiens	O14686	Anti Tag CoIP	33961781
Intra	WDR5	P61964	KMT2D	Homo sapiens	O14686	TAP	24981860
Intra	WDR5	P61964	KMT2D	Homo sapiens	O14686	Anti Tag CoIP	15960975
Intra	WDR5	P61964	KMT2D	Homo sapiens	O14686	Pull Down	17500065

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33	CILD33
Ciliary Dyskinesia, Primary, 33, Without Situs Inversus	Primary Ciliary Dyskinesia 33 Without Situs Inversus

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Kleefstra Syndrome

9q34.3 Microdeletion Syndrome	9q Subtelomeric Deletion Syndrome
9q- Syndrome	Chromosome 9q Deletion Syndrome
9q34.3 Deletion Syndrome	9qstds
Chromosome 9q34.3 Deletion Syndrome	Chromosome 9, Trisomy 9q

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Inhibitor	Purity	Phase Phase 1
HY-16994	OICR-0547	Inhibitor	99.93%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect Inhibitor Degrader Ligand Antagonist	Purity	Rare Diseases Unkown
HY-154949	WDR5-IN-6	Inhibitor	99.89%	Unkown
HY-148817	WDR5-0102	Inhibitor	97.02%	Unkown
HY-169389	OICR41114	Degrader	/	Unkown
HY-168475	DD0-2363	Inhibitor	/	Unkown
HY-161123	WDR5-IN-8	Inhibitor	/	Unkown
HY-172196	LH168		/	Unkown
HY-169415	DBL-6-13	Inhibitor	/	Unkown
HY-153331	DDO-2213	Inhibitor	/	Unkown
HY-159993	MR44397	Inhibitor	/	Unkown
HY-168488	WDR5 ligand 2	Ligand	/	Unkown
HY-157659	WDR5-MLL1 antagonist 1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WDR5	VGNC	VGNC:103886
Felis catus	WDR5	VGNC	VGNC:67039
Bos taurus	WDR5	VGNC	VGNC:58619
Canis familiaris	WDR5	VGNC	VGNC:48373
Mus musculus	WDR5	MGD	MGI:2155884
Rattus norvegicus	WDR5	RGD	RGD:1305159
Others	WDR5	NCBI

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