2. Gene
  3. TRMT6 - tRNA methyltransferase 6 non-catalytic subunit Gene

TRMT6 - tRNA methyltransferase 6 non-catalytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GCD10; CGI-09; Gcd10p

Gene ID: 51605 | Gene type: protein coding

About TRMT6

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRMT6 Products(2)

mRNA Protein Name
NM_001281467.2 NP_001268396.1 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2
NM_015939.5 NP_057023.2 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16043508 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA processing IDA
IDA: Inferred from direct assay
29072297 GOA
Cellular Component GO Annotation Evidence Reference Source
part of tRNA (m1A) methyltransferase complex IPI
IPI: Inferred from physical interaction
26470919 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT6 Protein Structure

Gcd10p

Gcd10p: Gcd10p family (18 - 289)

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  • 400
  • 497 a.a.
Protein Preferred Names Protein Names

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15094 TRMT6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRMT6 VGNC VGNC:66574
Rattus norvegicus TRMT6 RGD RGD:1308877
Bos taurus TRMT6 VGNC VGNC:36374
Canis familiaris TRMT6 VGNC VGNC:54738
Macaca mulatta TRMT6 VGNC VGNC:79294
Mus musculus TRMT6 MGD MGI:1914176