TRMT6 - tRNA methyltransferase 6 non-catalytic subunit Gene

Homo sapiens

Also known as GCD10; CGI-09; Gcd10p

Gene ID: 51605 | Gene type: protein coding

About TRMT6

This gene has 5 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in testis (RPKM 9.9), bone marrow (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

TRMT6 Products(2)

mRNA	Protein	Name
NM_001281467.2	NP_001268396.1	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2
NM_015939.5	NP_057023.2	tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16043508	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA processing	IDA IDA: Inferred from direct assay	29072297	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of tRNA (m1A) methyltransferase complex	IPI IPI: Inferred from physical interaction	26470919	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT6 Protein Structure

Gcd10p

0
100
200
300
400
497 a.a.

Protein Preferred Names

Protein Names

tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6

TRMT6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRMT6	Q9UJA5	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	TRMT6	Q9UJA5	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	TRMT6	Q9UJA5	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	TRMT6	Q9UJA5	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	TRMT6	Q9UJA5	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	TRMT6	Q9UJA5	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	TRMT6	Q9UJA5	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	TRMT6	Q9UJA5	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	TRMT6	Q9UJA5	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	TRMT6	Q9UJA5	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	TRMT6	Q9UJA5	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	TRMT6	Q9UJA5	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	TRMT6	Q9UJA5	TRMT61A	Homo sapiens	Q96FX7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15094	TRMT6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TRMT6	VGNC	VGNC:66574
Rattus norvegicus	TRMT6	RGD	RGD:1308877
Bos taurus	TRMT6	VGNC	VGNC:36374
Canis familiaris	TRMT6	VGNC	VGNC:54738
Macaca mulatta	TRMT6	VGNC	VGNC:79294
Mus musculus	TRMT6	MGD	MGI:1914176

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