SF3B6 - splicing factor 3b subunit 6 Gene

Homo sapiens

Also known as P14; Ht006; SAP14; SAP14a; SF3B14; CGI-110; HSPC175; SF3B14a

Gene ID: 51639 | Gene type: protein coding

About SF3B6

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,067,586-24,076,326 (from NCBI)

This gene has 2 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in bone marrow (RPKM 53.9), colon (RPKM 39.5) and 25 other tissues.

Summary

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]

SF3B6 Products(1)

mRNA	Protein	Name
NM_016047.4	NP_057131.1	splicing factor 3B subunit 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA binding	IDA IDA: Inferred from direct assay	16432215	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16432215	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	27720643	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U2-type spliceosomal complex	IPI IPI: Inferred from physical interaction	27720643	GOA
located in nucleus	IDA IDA: Inferred from direct assay	27720643	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B6 Protein Structure

RRM_1

0
100
125 a.a.

Protein Preferred Names

Protein Names

splicing factor 3B subunit 6

SF3b 14 kDa subunit

SF3B6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SF3B6	Q9Y3B4	SF3B1	Homo sapiens	O75533-1	X-Ray Diffraction	16432215
Intra	SF3B6	Q9Y3B4	SF3B1	Homo sapiens	O75533-1	GMS	16432215
Intra	SF3B6	Q9Y3B4	SF3B1	Homo sapiens	O75533-1	Pull Down	16432215
Intra	SF3B6	Q9Y3B4	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SF3B6	Q9Y3B4	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SF3B6	Q9Y3B4	SF3B1	Homo sapiens	O75533	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12765	SF3B6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SF3B6	VGNC	VGNC:97825
Mus musculus	SF3B6	MGD	MGI:1913305
Bos taurus	SF3B6	VGNC	VGNC:34513
Rattus norvegicus	SF3B6	RGD	RGD:2318878
Canis familiaris	SF3B6	VGNC	VGNC:46074
Felis catus	SF3B6	VGNC	VGNC:81219

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