2. Gene
  3. SF3B6 - splicing factor 3b subunit 6 Gene

SF3B6 - splicing factor 3b subunit 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as P14; Ht006; SAP14; SAP14a; SF3B14; CGI-110; HSPC175; SF3B14a

Gene ID: 51639 | Gene type: protein coding

About SF3B6

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,067,586-24,076,326 (from NCBI)

This gene has 2 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in bone marrow (RPKM 53.9), colon (RPKM 39.5) and 25 other tissues.

Summary

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]

SF3B6 Products(1)

mRNA Protein Name
NM_016047.4 NP_057131.1 splicing factor 3B subunit 6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA binding IDA
IDA: Inferred from direct assay
16432215 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16432215 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
27720643 GOA
Cellular Component GO Annotation Evidence Reference Source
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U2-type spliceosomal complex IPI
IPI: Inferred from physical interaction
27720643 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27720643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SF3B6 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (21 - 87)

  • 0
  • 100
  • 125 a.a.
Protein Preferred Names Protein Names

splicing factor 3B subunit 6

SF3b 14 kDa subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12765 SF3B6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SF3B6 VGNC VGNC:97825
Mus musculus SF3B6 MGD MGI:1913305
Bos taurus SF3B6 VGNC VGNC:34513
Rattus norvegicus SF3B6 RGD RGD:2318878
Canis familiaris SF3B6 VGNC VGNC:46074
Felis catus SF3B6 VGNC VGNC:81219