GINS2 - GINS complex subunit 2 Gene

Homo sapiens

Also known as PSF2; Pfs2; HSPC037

Gene ID: 51659 | Gene type: protein coding

About GINS2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,676,198-85,688,954 (from NCBI)

This gene has 3 transcripts (splice variants) and 208 orthologues. Broad expression in bone marrow (RPKM 11.1), lymph node (RPKM 10.1) and 20 other tissues.

Summary

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GINS2 Products(1)

mRNA	Protein	Name
NM_016095.3	NP_057179.1	DNA replication complex GINS protein PSF2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA unwinding involved in DNA replication	IDA IDA: Inferred from direct assay	22474384	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CMG complex	IPI IPI: Inferred from physical interaction	22474384	GOA
part of GINS complex	IPI IPI: Inferred from physical interaction	17417653	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22474384	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS2 Protein Structure

Sld5

0
100
185 a.a.

Protein Preferred Names

Protein Names

DNA replication complex GINS protein PSF2

GINS complex subunit 2 (Psf2 homolog)

GINS2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GINS2	Q9Y248	GINS4	Homo sapiens	Q9BRT9	Validated Y2H	25416956
Intra	GINS2	Q9Y248	GINS4	Homo sapiens	Q9BRT9	Anti Tag CoIP	33961781
Intra	GINS2	Q9Y248	GINS4	Homo sapiens	Q9BRT9	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Paronychia

Paronychia Inflammation	Onychomycosis
Fungal Nail Infection	Infected Nailfold
Onychia And Paronychia Of Finger	Onychia And Paronychia Of Toe
Fungal Infection Of The Nails

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05431	GINS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GINS2	VGNC	VGNC:99509
Canis familiaris	GINS2	VGNC	VGNC:41221
Bos taurus	GINS2	VGNC	VGNC:29361
Felis catus	GINS2	VGNC	VGNC:62554
Mus musculus	GINS2	MGD	MGI:1921019
Rattus norvegicus	GINS2	RGD	RGD:1311055

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