2. Gene
  3. GINS4 - GINS complex subunit 4 Gene

GINS4 - GINS complex subunit 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLD5

Gene ID: 84296 | Gene type: protein coding

About GINS4

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,529,261-41,545,030 (from NCBI)

This gene has 9 transcripts (splice variants) and 202 orthologues. Broad expression in lymph node (RPKM 2.4), appendix (RPKM 2.0) and 23 other tissues.

Summary

The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

GINS4 Products(1)

mRNA Protein Name
NM_032336.3 NP_115712.1 DNA replication complex GINS protein SLD5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA unwinding involved in DNA replication IDA
IDA: Inferred from direct assay
22474384 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CMG complex IPI
IPI: Inferred from physical interaction
22474384 GOA
part of GINS complex IPI
IPI: Inferred from physical interaction
17417653 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22474384 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GINS4 Protein Structure

Sld5

Sld5: GINS complex protein (61 - 126)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

DNA replication complex GINS protein SLD5

SLD5 homolog

GINS4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra GINS4 Q9BRT9 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra GINS4 Q9BRT9 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra GINS4 Q9BRT9 KIF16B Homo sapiens Q96L93-6
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 KIF16B Homo sapiens Q96L93-6
Y2H Array
32296183
Intra GINS4 Q9BRT9 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra GINS4 Q9BRT9 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 SIK1B Homo sapiens A0A0B4J2F2
Y2H Array
32296183
Intra GINS4 Q9BRT9 SIK1B Homo sapiens A0A0B4J2F2
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 BIN3 Homo sapiens Q9NQY0
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 BIN3 Homo sapiens Q9NQY0
Validated Y2H
32296183
Intra GINS4 Q9BRT9 BIN3 Homo sapiens Q9NQY0
Y2H Array
32296183
Intra GINS4 Q9BRT9 DMAP1 Homo sapiens Q9NPF5
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 DMAP1 Homo sapiens Q9NPF5
Validated Y2H
32296183
Intra GINS4 Q9BRT9 DMAP1 Homo sapiens Q9NPF5
Y2H Array
32296183
Intra GINS4 Q9BRT9 CTNNBIP1 Homo sapiens Q9NSA3
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 CTNNBIP1 Homo sapiens Q9NSA3
Validated Y2H
32296183
Intra GINS4 Q9BRT9 CTNNBIP1 Homo sapiens Q9NSA3
Y2H Array
32296183
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Y2H Prey Pooling
32296183
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Y2H Array
25416956
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Y2H Array
32296183
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Validated Y2H
32296183
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Y2H Array
31515488
Intra GINS4 Q9BRT9 GINS2 Homo sapiens Q9Y248
Y2H Prey Pooling
25416956
Intra GINS4 Q9BRT9 MCMBP Homo sapiens Q9BTE3
Anti Bait CoIP
22540012
Intra GINS4 Q9BRT9 LHX8 Homo sapiens Q68G74
Y2H Array
32296183
Intra GINS4 Q9BRT9 LHX8 Homo sapiens Q68G74
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05433 GINS4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GINS4 VGNC VGNC:41223
Mus musculus GINS4 MGD MGI:1923847
Rattus norvegicus GINS4 RGD RGD:1307397
Bos taurus GINS4 VGNC VGNC:29363
Felis catus GINS4 VGNC VGNC:62556
Macaca mulatta GINS4 VGNC VGNC:73021