ASB1 - ankyrin repeat and SOCS box containing 1 Gene

Homo sapiens

Also known as ASB-1

Gene ID: 51665 | Gene type: protein coding

About ASB1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,426,927-238,452,250 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 9.2), heart (RPKM 8.5) and 25 other tissues.

Summary

The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]

ASB1 Products(2)

mRNA	Protein	Name
NM_001040445.3	NP_001035535.1	ankyrin repeat and SOCS box protein 1 isoform 1
NM_001330196.2	NP_001317125.1	ankyrin repeat and SOCS box protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
contributes to ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16325183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16325183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16325183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB1 Protein Structure

Ank_2

SOCS_box

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 1

ASB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASB1	Q9Y576	CUL5	Homo sapiens	Q93034	Anti Tag CoIP	16325183
Intra	ASB1	Q9Y576	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ASB1	Q9Y576	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ASB1	Q9Y576	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ASB1	Q9Y576	RNF7	Homo sapiens	Q9UBF6	Anti Tag CoIP	16325183
Intra	ASB1	Q9Y576	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	ASB1	Q9Y576	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ASB1	Q9Y576	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Ebstein Anomaly

Ebstein'S Anomaly	Ebstein'S Anomaly Of Common Atrioventricular Valve
Ebstein'S Anomaly Of Right Atrioventricular Valve	Ebstein'S Anomaly Of Tricuspid Valve
Ebstein'S Malformation	Ebstein Malformation Of The Tricuspid Valve
Ebstein Anomaly Of The Tricuspid Valve	Ebstein Disease
Accessory Tricuspid Valve Tissue	Congenital Ebstein Deformity Of Tricuspid Valve
Ebstein Syndrome	Ebstein Cardiopathy
Ebstein Anomaly Of Tricuspid Valve

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01058	ASB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASB1	VGNC	VGNC:26186
Felis catus	ASB1	VGNC	VGNC:59955
Mus musculus	ASB1	MGD	MGI:1929735
Macaca mulatta	ASB1	VGNC	VGNC:69839
Rattus norvegicus	ASB1	RGD	RGD:1310760
Others	ASB1	NCBI

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