RNF7 - ring finger protein 7 Gene

Homo sapiens

Also known as SAG; ROC2; rbx2; CKBBP1

Gene ID: 9616 | Gene type: protein coding

About RNF7

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:141,738,298-141,747,560 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues.

Summary

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, Casein Kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF7 Products(3)

mRNA	Protein	Name
NM_001201370.2	NP_001188299.1	RING-box protein 2 isoform 4
NM_014245.5	NP_055060.1	RING-box protein 2 isoform 1
NM_183237.3	NP_899060.1	RING-box protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NEDD8 ligase activity	IDA IDA: Inferred from direct assay	19250909	GOA
enables cullin family protein binding	IDA IDA: Inferred from direct assay	10230407	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16874460	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	31387940	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21980433	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	27910872	GOA
involved in protein neddylation	IDA IDA: Inferred from direct assay	19250909	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	21980433	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	16874460	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	16874460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF7 Protein Structure

zf-rbx1

0
100
113 a.a.

Protein Preferred Names

Protein Names

RING-box protein 2

CKII beta-binding protein 1

Related Diseases

Diseases

Alias

Brachydactyly, Type E2

Brachydactyly Type E2	BDE2
Brachydactyly E2

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12096	RNF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF7	MGD	MGI:1337096
Canis familiaris	RNF7	VGNC	VGNC:45675
Macaca mulatta	RNF7	VGNC	VGNC:76707
Bos taurus	RNF7	VGNC	VGNC:34072
Felis catus	RNF7	VGNC	VGNC:102814
Rattus norvegicus	RNF7	RGD	RGD:1311048
Others	RNF7	NCBI

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