2. Gene
  3. ACSL5 - acyl-CoA synthetase long chain family member 5 Gene

ACSL5 - acyl-CoA synthetase long chain family member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACS2; ACS5; FACL5

Gene ID: 51703 | Gene type: protein coding

About ACSL5

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:112,374,116-112,428,376 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 203.8), duodenum (RPKM 170.4) and 10 other tissues.

Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A Ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACSL5 Products(4)

mRNA Protein Name
NM_001387037.1 NP_001373966.1 long-chain-fatty-acid--CoA ligase 5 isoform c
NM_016234.4 NP_057318.2 long-chain-fatty-acid--CoA ligase 5 isoform a
NM_203379.2 NP_976313.1 long-chain-fatty-acid--CoA ligase 5 isoform b
NM_203380.2 NP_976314.1 long-chain-fatty-acid--CoA ligase 5 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
17681178 GOA
enables long-chain fatty acid-CoA ligase activity IMP
IMP: Inferred from mutant phenotype
22633490 GOA
enables oleoyl-CoA ligase activity IDA
IDA: Inferred from direct assay
33191500 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
17681178 GOA
involved in long-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
22633490 GOA
involved in regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
17681178 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17681178 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
17681178 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
24269233 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACSL5 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (101 - 547)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

long-chain-fatty-acid--CoA ligase 5

FACL5 for fatty acid coenzyme A ligase 5

ACSL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ACSL5 Q9ULC5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SELI Homo sapiens Q8WU57
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 SELI Homo sapiens Q8WU57
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
ACSL5 Q9ULC5 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra
ACSL5 Q9ULC5 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glioma
Non-Syndromic X-Linked Intellectual Disability 63

Acsl4-Related Intellectual Disability

Mrx63

Mrx68

X-Linked Mental Retardation 68
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16256 Acsl5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00203 ACSL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACSL5 VGNC VGNC:69431
Canis familiaris ACSL5 VGNC VGNC:37535
Mus musculus ACSL5 MGD MGI:1919129
Rattus norvegicus ACSL5 RGD RGD:69402
Bos taurus ACSL5 VGNC VGNC:25567
Felis catus ACSL5 VGNC VGNC:59537