MSRB1 - methionine sulfoxide reductase B1 Gene

Homo sapiens

Also known as SELR; SELX; SepR; SEPX1; HSPC270; SELENOR; SELENOX

Gene ID: 51734 | Gene type: protein coding

About MSRB1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,938,229-1,943,199 (from NCBI)

This gene has 5 transcripts (splice variants), 282 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 37.2), liver (RPKM 35.6) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair Enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to Other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]

MSRB1 Products(3)

mRNA	Protein	Name
NM_001382264.1	NP_001369193.1	methionine-R-sulfoxide reductase B1 isoform 2
NM_001382265.1	NP_001369194.1	methionine-R-sulfoxide reductase B1 isoform 3
NM_016332.4	NP_057416.1	methionine-R-sulfoxide reductase B1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23805218	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRB1 Protein Structure

SelR

0
100
116 a.a.

Protein Preferred Names

Protein Names

methionine-R-sulfoxide reductase B1

selenoprotein R

MSRB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	FRAP	23805218
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	FRET	23805218
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	Pull Down	23805218
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	Y2H	23805218
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	Anti Tag CoIP	23805218
Intra	MSRB1	Q9NZV6	CLU	Homo sapiens	P10909-5	Anti Bait CoIP	23805218
Intra	MSRB1	Q9NZV6	IFT88	Homo sapiens	Q13099	Y2H Array	32296183
Intra	MSRB1	Q9NZV6	IFT88	Homo sapiens	Q13099	Y2H Prey Pooling	32296183
Intra	MSRB1	Q9NZV6	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MSRB1	Q9NZV6	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MSRB1	Q9NZV6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	MSRB1	Q9NZV6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	MSRB1	Q9NZV6	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	MSRB1	Q9NZV6	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Staphyloenterotoxemia

Staphylococcal Food Poisoning	Staphylococcal Toxaemia Due To Food
Staphyloenterotoxicosis

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Progressive Myoclonus Epilepsy 1a

Epm1a

Commensal Bacterial Infectious Disease

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08726	MSRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSRB1	VGNC	VGNC:99524
Mus musculus	MSRB1	MGD	MGI:1351642
Rattus norvegicus	MSRB1	RGD	RGD:1583243
Felis catus	MSRB1	VGNC	VGNC:80602

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