PGC - progastricsin Gene

Homo sapiens

Also known as PEPC; PGII

Gene ID: 5225 | Gene type: protein coding

About PGC

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,736,711-41,747,397 (from NCBI)

This gene has 4 transcripts (splice variants), 165 orthologues and 9 paralogues. Restricted expression toward stomach (RPKM 7385.5).

Summary

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive Enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This Enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the Enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this Enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

PGC Products(2)

mRNA	Protein	Name
NM_001166424.2	NP_001159896.1	gastricsin isoform 2 preproprotein
NM_002630.4	NP_002621.1	gastricsin isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	12759353	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of antibacterial peptide production	IMP IMP: Inferred from mutant phenotype	12759353	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12759353	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGC Protein Structure

A1_Propeptide

Asp

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

gastricsin

pepsin C

Recombinant PGC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77131	Pepsinogen C/PGC Protein, Human (His)	P20142-1/NP_002621.1 (I153-I239)	≥95%
HY-P77132	Pepsinogen C/PGC Protein, Human (HEK293, His)	P20142-1/NP_002621.1 (A17-A388)	≥95%

Related Diseases

Diseases

Alias

Gastritis

Acute Gastric Mucosal Erosion	Erosive Gastritis
Erosive Gastropathy	Gastritis Erosive
Idiopathic Erosive/Hemorrhagic Gastritis	Inflammation Of Gastric Mucosa
Gastroduodenitis	Gastritis Nos
Noninfectious Gastroenteritis	Nonbacterial Gastroenteritis Of Infant
Acute Gastric Infection	Acute Simple Gastritis
Chronic Antral Gastritis	Chronic Fundal Gastritis
Chronic Simple Gastritis	Acute Gastroduodenitis
Acute Antral Gastritis	Acute Erosive Gastritis
Bile Reflux Gastritis	Gastritis Due To Biliary Reflux

Hypogonadotropic Hypogonadism 14 With Or Without Anosmia

HH14	Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia

Gastroesophageal Reflux

Gastroesophageal Reflux Disease	Gerd
GER	Gastroesophageal Reflux, Pediatric
Acid Reflux	Gastresophageal Reflux
Gastro-Esophageal Reflux	Gerd - Gastro-Esophageal Reflux Disease

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0378	D-Mannitol		99.93%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3624	Cenderitide	Agonist	99.84%	Phase 2

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101491	SR-18292	Inhibitor	99.82%	Unkown
HY-17538	ZLN005	Activator	99.92%	Unkown
HY-113960	ERRα antagonist-1	Antagonist	99.71%	Unkown
HY-N7439	Mogroside VI B	Activator	98.97%	Unkown
HY-P5763	Phoenixin-20		99.68%	Unkown
HY-17538S	ZLN005-d4	Activator	99.52%	Unkown
HY-P3455	Ac-SVVVRT-NH2	Modulator	98.50%	Unkown
HY-130479	AdipoR agonist 1		≥98.0%	Unkown
HY-121152	Chiisanoside		/	Unkown
HY-125535	OSU-53		/	Unkown
HY-N12011	11-Oxoisomogroside V	Activator	/	Unkown
HY-P10720	C-Type Natriuretic Peptide (1-53), Porcine, Rat,mouse		/	Unkown
HY-P5763A	Phoenixin-20 TFA		/	Unkown
HY-RS10380	PGC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119790	Palmitoyllactic acid		/	Unkown
HY-125629	Primordazine B		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PGC	RGD	RGD:3943
Felis catus	PGC	VGNC	VGNC:68812
Bos taurus	PGC	VGNC	VGNC:32785
Mus musculus	PGC	MGD	MGI:98909
Canis familiaris	PGC	VGNC	VGNC:57228
Macaca mulatta	PGC	VGNC	VGNC:83442
Others	PGC	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.