2. Metabolic Enzyme/Protease Autophagy
  3. PGC-1α Autophagy
  4. ZLN005

ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).

For research use only. We do not sell to patients.

ZLN005 Chemical Structure

ZLN005 Chemical Structure

CAS No. : 49671-76-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mg USD 66 In-stock
25 mg USD 134 In-stock
50 mg USD 213 In-stock
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Customer Review

Based on 34 publication(s) in Google Scholar

Other Forms of ZLN005:

ZLN005 Related Antibodies

Top Publications Citing Use of Products

32 Publications Citing Use of MCE ZLN005

WB

    ZLN005 purchased from MedChemExpress. Usage Cited in: Cytokine. 2023 Mar 27;165:156186.  [Abstract]

    ZLN005 (10, 20 μM; 6 h) increases the protein levels of TAC1, Bax, Bim, cleaved Caspase 1 (C-CAP1), and cleaved Caspase 9 (C-CAP9) in a dose-dependent manner in HL-1 cells.

    ZLN005 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2018 Jun 6;19(6). pii: E1691.  [Abstract]

    The protein expression levels of COI~IV and the phosphorylation levels of Akt and GSK3β in the NEFA+ZLN005 group are significantly higher than in the non-esterified fatty acid (NEFA) group.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

    IC50 & Target

    Peroxisome proliferator-activated receptor-γ coactivator-1α[1]
    In Vitro

    ZLN005 (2.5-20 μM; 24 hours ) activates AMPK in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ZLN005 Related Antibodies

    Western Blot Analysis[1]

    Cell Line: L6 myotubes
    Concentration: 2.5, 5, 10, 20 μM
    Incubation Time: 24 hours
    Result: Dose-dependent activation of AMPK.
    In Vivo

    ZLN005 (15 mg/kg; p.o.; per day for 4 weeks) decreases random blood glucose and fasting blood glucose levels over 4 weeks compared with lean mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Eight-week-old db/db mice[1]
    Dosage: 15 mg/kg
    Administration: Oral administration; per day for 4 weeks
    Result: Random blood glucose and fasting blood glucose levels decreased significantly over 4 weeks compared with lean mice.
    Molecular Weight

    250.34

    Formula

    C17H18N2
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light brown

    SMILES

    CC(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)(C)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 22 mg/mL (87.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 5 mg/mL (19.97 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9946 mL 19.9728 mL 39.9457 mL
    5 mM 0.7989 mL 3.9946 mL 7.9891 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.2 mg/mL (8.79 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.2 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1.25 mg/mL (4.99 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 1.67 mg/mL (6.67 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.92%

    COA (245 KB) LCMS (110 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 3.9946 mL 19.9728 mL 39.9457 mL 99.8642 mL
    5 mM 0.7989 mL 3.9946 mL 7.9891 mL 19.9728 mL
    10 mM 0.3995 mL 1.9973 mL 3.9946 mL 9.9864 mL
    15 mM 0.2663 mL 1.3315 mL 2.6630 mL 6.6576 mL
    DMSO 20 mM 0.1997 mL 0.9986 mL 1.9973 mL 4.9932 mL
    25 mM 0.1598 mL 0.7989 mL 1.5978 mL 3.9946 mL
    30 mM 0.1332 mL 0.6658 mL 1.3315 mL 3.3288 mL
    40 mM 0.0999 mL 0.4993 mL 0.9986 mL 2.4966 mL
    50 mM 0.0799 mL 0.3995 mL 0.7989 mL 1.9973 mL
    60 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6644 mL
    80 mM 0.0499 mL 0.2497 mL 0.4993 mL 1.2483 mL
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    ZLN005 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ZLN00549671-76-3ZLN 005ZLN-005PGC-1αAutophagyPPARγ coactivator-1αInhibitorinhibitorinhibit

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