PKNOX1 - PBX/knotted 1 homeobox 1 Gene

Homo sapiens

Also known as PREP1; pkonx1c

Gene ID: 5316 | Gene type: protein coding

About PKNOX1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,974,562-43,033,931 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.8) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in angiogenesis and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

PKNOX1 Products(3)

mRNA	Protein	Name
NM_001286258.2	NP_001273187.1	homeobox protein PKNOX1 isoform 2
NM_001320694.2	NP_001307623.1	homeobox protein PKNOX1 isoform 3
NM_004571.5	NP_004562.2	homeobox protein PKNOX1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19559479	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKNOX1 Protein Structure

Homeobox_KN

0
100
200
300
400
436 a.a.

Protein Preferred Names

Protein Names

homeobox protein PKNOX1

PBX/knotted homeobox 1

PKNOX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PKNOX1	P55347	BORCS6	Homo sapiens	Q96GS4	Complementation	32296183
Intra	PKNOX1	P55347	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	32296183
Intra	PKNOX1	P55347	PBX4	Homo sapiens	Q9BYU1	Validated Y2H	32296183
Intra	PKNOX1	P55347	HMGB2	Homo sapiens	P26583	Y2H Prey Pooling	32296183
Intra	PKNOX1	P55347	FAM110B	Homo sapiens	Q8TC76	Validated Y2H	32296183
Intra	PKNOX1	P55347	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
Intra	PKNOX1	P55347	PBX1	Homo sapiens	P40424	Anti Tag CoIP	33961781
Intra	PKNOX1	P55347	PBX1	Homo sapiens	P40424	Comigration in SDS	25856340
Intra	PKNOX1	P55347	PBX1	Homo sapiens	P40424	GMS	25856340
Intra	PKNOX1	P55347	PBX1	Homo sapiens	P40424	Y2H Fragment Pooling	35914814
Intra	PKNOX1	P55347	PBX2	Homo sapiens	P40425	Y2H Fragment Pooling	35914814
Intra	PKNOX1	P55347	PBX2	Homo sapiens	P40425	Imaging	9482739
Intra	PKNOX1	P55347	PBX2	Homo sapiens	P40425	Y2H	19559479
Intra	PKNOX1	P55347	PBX2	Homo sapiens	P40425	Anti Tag CoIP	33961781
Intra	PKNOX1	P55347	BLOC1S5	Homo sapiens	Q8TDH9	Validated Y2H	32296183
Intra	PKNOX1	P55347	FHL2	Homo sapiens	Q14192	Validated Y2H	32296183
Intra	PKNOX1	P55347	MPP3	Homo sapiens	Q13368	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 4

ETL4	Epilepsy, Occipitotemporal Lobe, And Migraine With Aura
Epolm	Familial Temporal Lobe Epilepsy 4
Occipitotemporal Lobe Epilepsy And Migraine With Aura

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10609	PKNOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PKNOX1	VGNC	VGNC:44614
Macaca mulatta	PKNOX1	VGNC	VGNC:76150
Felis catus	PKNOX1	VGNC	VGNC:102804
Rattus norvegicus	PKNOX1	RGD	RGD:1305003
Bos taurus	PKNOX1	VGNC	VGNC:32948
Mus musculus	PKNOX1	MGD	MGI:1201409

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