PBX4 - PBX homeobox 4 Gene

Homo sapiens

Gene ID: 80714 | Gene type: protein coding

About PBX4

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,561,713-19,618,687 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 12 paralogues. Broad expression in thyroid (RPKM 3.9), testis (RPKM 2.5) and 18 other tissues.

Summary

This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

PBX4 Products(1)

mRNA	Protein	Name
NM_025245.3	NP_079521.1	pre-B-cell leukemia transcription factor 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PBX4 Protein Structure

PBC

Homeobox

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor 4

homeobox protein PBX4

PBX4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PBX4	Q9BYU1	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	PBX4	Q9BYU1	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	ARHGEF3	Homo sapiens	Q9NR81	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	PBX4	Q9BYU1	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	PBX4	Q9BYU1	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	25416956
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	PBX4	Q9BYU1	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	CPNE7	Homo sapiens	Q9UBL6-2	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	HOXD4	Homo sapiens	P09016	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	HOXD4	Homo sapiens	P09016	Y2H Array	32296183
Intra	PBX4	Q9BYU1	PKNOX1	Homo sapiens	P55347	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	PKNOX1	Homo sapiens	P55347	Y2H Array	32296183
Intra	PBX4	Q9BYU1	PKNOX1	Homo sapiens	P55347	Anti Tag CoIP	33961781
Intra	PBX4	Q9BYU1	CHCHD2	Homo sapiens	Q9Y6H1	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	PKNOX2	Homo sapiens	Q96KN3	Y2H Array	32296183
Intra	PBX4	Q9BYU1	PKNOX2	Homo sapiens	Q96KN3	Anti Tag CoIP	33961781
Intra	PBX4	Q9BYU1	PKNOX2	Homo sapiens	Q96KN3	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	CCM2L	Homo sapiens	Q9NUG4	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	HOXB2	Homo sapiens	P14652	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	HOXB2	Homo sapiens	P14652	Y2H Array	32296183
Intra	PBX4	Q9BYU1	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	PACSIN2	Homo sapiens	Q9UNF0	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	IPO13	Homo sapiens	O94829	Y2H Prey Pooling	25416956
Intra	PBX4	Q9BYU1	IPO13	Homo sapiens	O94829	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	IPO13	Homo sapiens	O94829	Y2H Array	32296183
Intra	PBX4	Q9BYU1	SERTAD1	Homo sapiens	Q9UHV2	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	SERTAD1	Homo sapiens	Q9UHV2	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	SERTAD1	Homo sapiens	Q9UHV2	Y2H Array	32296183
Intra	PBX4	Q9BYU1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	MEIS2	Homo sapiens	O14770-4	Y2H Array	32296183
Intra	PBX4	Q9BYU1	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	PBX4	Q9BYU1	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	PBX4	Q9BYU1	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Cantu Syndrome

Hypertrichotic Osteochondrodysplasia	Hypertrichotic Osteochondrodysplasia Cantu Type
Cantú Syndrome	Craniofaciocardioskeletal Syndrome
Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome	Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum
Congenital Hypertrichosis-Coarse Facial Features Spectrum	HTOCD
Osteochondrodysplasia, Hypertrichotic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10109	PBX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PBX4	VGNC	VGNC:44289
Felis catus	PBX4	VGNC	VGNC:64057
Bos taurus	PBX4	VGNC	VGNC:32610
Rattus norvegicus	PBX4	RGD	RGD:1305100
Mus musculus	PBX4	MGD	MGI:1931321

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