STX18 - syntaxin 18 Gene

Homo sapiens

Also known as Ufe1

Gene ID: 53407 | Gene type: protein coding

About STX18

Cytogenetic location: 4p16.3-p16.2 Genomic coordinates (GRCh38): 4:4,418,968-4,542,343 (from NCBI)

This gene has 10 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in endometrium (RPKM 20.8), skin (RPKM 17.0) and 25 other tissues.

Summary

This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes Other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

STX18 Products(4)

mRNA	Protein	Name
NM_001346281.2	NP_001333210.1	syntaxin-18 isoform 2
NM_001346282.2	NP_001333211.1	syntaxin-18 isoform 3
NM_001346300.2	NP_001333229.1	syntaxin-18 isoform 3
NM_016930.4	NP_058626.1	syntaxin-18 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15029241	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum membrane organization	IMP IMP: Inferred from mutant phenotype	19401338	GOA
involved in positive regulation of ER to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	10788491	GOA
involved in positive regulation of organelle assembly	IMP IMP: Inferred from mutant phenotype	19401338	GOA
involved in regulation of Golgi organization	IMP IMP: Inferred from mutant phenotype	19401338	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10788491	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX18 Protein Structure

Syntaxin-18_N

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

syntaxin-18

cell growth-inhibiting gene 9 protein

STX18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STX18	Q9P2W9	SEC22B	Homo sapiens	O75396	Anti Tag CoIP	35271311
Intra	STX18	Q9P2W9	SEC22B	Homo sapiens	O75396	Pull Down	19369418
Intra	STX18	Q9P2W9	SEC22B	Homo sapiens	O75396	Anti Bait CoIP	19369418
Intra	STX18	Q9P2W9	USE1	Homo sapiens	Q9NZ43	Anti Tag CoIP	33961781
Intra	STX18	Q9P2W9	USE1	Homo sapiens	Q9NZ43	Anti Tag CoIP	35271311
Intra	STX18	Q9P2W9	USE1	Homo sapiens	Q9NZ43	Anti Bait CoIP	19369418

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Infantile Liver Failure Syndrome

Infantile Liver Failure

Pelger-Huet Anomaly

PHA	Pelger-Huët Anomaly
Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy And Skeletal Abnormalities	Pelger Huet Anomaly
Pelger-Huet Nuclear Anomaly

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13979	STX18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STX18	VGNC	VGNC:46952
Rattus norvegicus	STX18	RGD	RGD:1310058
Macaca mulatta	STX18	VGNC	VGNC:100274
Bos taurus	STX18	VGNC	VGNC:35434
Felis catus	STX18	VGNC	VGNC:65809
Mus musculus	STX18	MGD	MGI:1918366

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