SEC22B - SEC22 homolog B, vesicle trafficking protein Gene

Homo sapiens

Also known as ERS-24; SEC22L1

Gene ID: 9554 | Gene type: protein coding

About SEC22B

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:120,150,898-120,176,520 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

SEC22B Products(2)

mRNA	Protein	Name
NM_004892.6	NP_004883.3	vesicle-trafficking protein SEC22b precursor
NM_004892.6	NP_004883.3	vesicle-trafficking protein SEC22b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15272311	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	21242315	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	21242315	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ER to Golgi transport vesicle membrane	IDA IDA: Inferred from direct assay	17499046	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-trafficking protein SEC22b

ER-Golgi SNARE of 24 kDa

Related Diseases

Diseases

Alias

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Pontiac Fever

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12611	SEC22B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEC22B	VGNC	VGNC:59190
Rattus norvegicus	SEC22B	RGD	RGD:1309988
Felis catus	SEC22B	VGNC	VGNC:99810
Mus musculus	SEC22B	MGD	MGI:1338759
Canis familiaris	SEC22B	VGNC	VGNC:99805

Name
Email *

	Sorry, but the email address you supplied was invalid.