SEC22B - SEC22 homolog B, vesicle trafficking protein Gene

Homo sapiens

Also known as ERS-24; SEC22L1

Gene ID: 9554 | Gene type: protein coding

About SEC22B

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:120,150,898-120,176,520 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

SEC22B Products(2)

mRNA	Protein	Name
NM_004892.6	NP_004883.3	vesicle-trafficking protein SEC22b precursor
NM_004892.6	NP_004883.3	vesicle-trafficking protein SEC22b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15272311	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	21242315	GOA
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	21242315	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ER to Golgi transport vesicle membrane	IDA IDA: Inferred from direct assay	17499046	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-trafficking protein SEC22b

ER-Golgi SNARE of 24 kDa

SEC22B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEC22B	O75396	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	SEC22B	O75396	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	SEC22B	O75396	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	SEC22B	O75396	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	SEC22B	O75396	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	SEC22B	O75396	DPM3	Homo sapiens	Q9P2X0-2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	DPM3	Homo sapiens	Q9P2X0-2	Validated Y2H	32296183
Intra	SEC22B	O75396	DPM3	Homo sapiens	Q9P2X0-2	Y2H Array	32296183
Intra	SEC22B	O75396	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	SEC22B	O75396	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	SEC22B	O75396	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	SEC22B	O75396	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	HIBADH	Homo sapiens	P31937	Validated Y2H	32296183
Intra	SEC22B	O75396	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	SEC22B	O75396	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SEC22B	O75396	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	SEC22B	O75396	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	SEC22B	O75396	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	SEC22B	O75396	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	SEC22B	O75396	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	AIG1	Homo sapiens	Q9NVV5-2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	SEC22B	O75396	AIG1	Homo sapiens	Q9NVV5-2	Y2H Array	32296183
Intra	SEC22B	O75396	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	SEC22B	O75396	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	SEC22B	O75396	TMEM229B	Homo sapiens	Q8NBD8	Y2H Array	32296183
Intra	SEC22B	O75396	TMEM229B	Homo sapiens	Q8NBD8	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TMEM229B	Homo sapiens	Q8NBD8	Validated Y2H	32296183
Intra	SEC22B	O75396	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	SEC22B	O75396	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	SEC22B	O75396	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SEC22B	O75396	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SEC22B	O75396	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SEC22B	O75396	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SEC22B	O75396	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	GJB6	Homo sapiens	O95452	Validated Y2H	32296183
Intra	SEC22B	O75396	GJB6	Homo sapiens	O95452	Y2H Array	32296183
Intra	SEC22B	O75396	GJB6	Homo sapiens	O95452	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CLRN1	Homo sapiens	P58418	Validated Y2H	32296183
Intra	SEC22B	O75396	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	SEC22B	O75396	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	SLC35C2	Homo sapiens	Q9NQQ7-3	Validated Y2H	32296183
Intra	SEC22B	O75396	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Array	32296183
Intra	SEC22B	O75396	SLC35C2	Homo sapiens	Q9NQQ7-3	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	SEC22B	O75396	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SEC22B	O75396	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	SEC22B	O75396	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	SEC22B	O75396	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	SEC22B	O75396	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	SEC22B	O75396	CERS6	Homo sapiens	Q6ZMG9-2	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CERS6	Homo sapiens	Q6ZMG9-2	Validated Y2H	32296183
Intra	SEC22B	O75396	CERS6	Homo sapiens	Q6ZMG9-2	Y2H Array	32296183
Intra	SEC22B	O75396	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	SEC22B	O75396	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	SEC22B	O75396	LHFPL1	Homo sapiens	Q86WI0	Y2H Array	32296183
Intra	SEC22B	O75396	LHFPL1	Homo sapiens	Q86WI0	Validated Y2H	32296183
Intra	SEC22B	O75396	LHFPL1	Homo sapiens	Q86WI0	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SEC22B	O75396	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SEC22B	O75396	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	SEC22B	O75396	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	SEC22B	O75396	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	SEC22B	O75396	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	SEC22B	O75396	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	SEC22B	O75396	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	SEC22B	O75396	NDUFAF2	Homo sapiens	Q8N183	Validated Y2H	32296183
Intra	SEC22B	O75396	NDUFAF2	Homo sapiens	Q8N183	Y2H Array	32296183
Intra	SEC22B	O75396	NDUFAF2	Homo sapiens	Q8N183	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	LHFPL5	Homo sapiens	Q8TAF8	Validated Y2H	32296183
Intra	SEC22B	O75396	LHFPL5	Homo sapiens	Q8TAF8	Y2H Array	32296183
Intra	SEC22B	O75396	LHFPL5	Homo sapiens	Q8TAF8	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	ABHD16A	Homo sapiens	O95870	Validated Y2H	32296183
Intra	SEC22B	O75396	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	SEC22B	O75396	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	IFNGR2	Homo sapiens	P38484	Validated Y2H	32296183
Intra	SEC22B	O75396	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	SEC22B	O75396	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	GJB5	Homo sapiens	O95377	Validated Y2H	32296183
Intra	SEC22B	O75396	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	SEC22B	O75396	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	SEC22B	O75396	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SEC22B	O75396	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	SEC22B	O75396	GORAB	Homo sapiens	Q5T7V8	Validated Y2H	32296183
Intra	SEC22B	O75396	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	SEC22B	O75396	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	SEC22B	O75396	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	SEC22B	O75396	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	SEC22B	O75396	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	SEC22B	O75396	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	SEC22B	O75396	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SEC22B	O75396	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SEC22B	O75396	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	SEC22B	O75396	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	SEC22B	O75396	STX5	Homo sapiens	Q13190	Anti Tag CoIP	33961781
Intra	SEC22B	O75396	STX5	Homo sapiens	Q13190	Anti Bait CoIP	22153078
Intra	SEC22B	O75396	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	SEC22B	O75396	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	SEC22B	O75396	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	SEC22B	O75396	STX18	Homo sapiens	Q9P2W9	Anti Tag CoIP	33961781
Intra	SEC22B	O75396	STX18	Homo sapiens	Q9P2W9	Anti Tag CoIP	28514442
Intra	SEC22B	O75396	CLDN7	Homo sapiens	O95471	Validated Y2H	32296183
Intra	SEC22B	O75396	CLDN7	Homo sapiens	O95471	Y2H Array	32296183
Intra	SEC22B	O75396	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	SEC22B	O75396	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	SEC22B	O75396	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183
Intra	SEC22B	O75396	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	SEC22B	O75396	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	SEC22B	O75396	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SEC22B	O75396	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	SEC22B	O75396	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SEC22B	O75396	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	SEC22B	O75396	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	SEC22B	O75396	KIR2DL3	Homo sapiens	P43628	Validated Y2H	32296183
Intra	SEC22B	O75396	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	SEC22B	O75396	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	RHBDD1	Homo sapiens	Q8TEB9	Y2H Array	32296183
Intra	SEC22B	O75396	RHBDD1	Homo sapiens	Q8TEB9	Y2H Prey Pooling	32296183
Intra	SEC22B	O75396	RHBDD1	Homo sapiens	Q8TEB9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Pontiac Fever

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12611	SEC22B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEC22B	VGNC	VGNC:59190
Rattus norvegicus	SEC22B	RGD	RGD:1309988
Felis catus	SEC22B	VGNC	VGNC:99810
Mus musculus	SEC22B	MGD	MGI:1338759
Canis familiaris	SEC22B	VGNC	VGNC:99805

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