2. Gene
  3. SEC22B - SEC22 homolog B, vesicle trafficking protein Gene

SEC22B - SEC22 homolog B, vesicle trafficking protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERS-24; SEC22L1

Gene ID: 9554 | Gene type: protein coding

About SEC22B

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:120,150,898-120,176,520 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009]

SEC22B Products(2)

mRNA Protein Name
NM_004892.6 NP_004883.3 vesicle-trafficking protein SEC22b precursor
NM_004892.6 NP_004883.3 vesicle-trafficking protein SEC22b precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15272311 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
21242315 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
21242315 GOA
Cellular Component GO Annotation Evidence Reference Source
located in ER to Golgi transport vesicle membrane IDA
IDA: Inferred from direct assay
17499046 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
15308636 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-trafficking protein SEC22b

ER-Golgi SNARE of 24 kDa

SEC22B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SEC22B O75396 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
SEC22B O75396 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
SEC22B O75396 RELL2 Homo sapiens Q8NC24
Validated Y2H
32296183
Intra
SEC22B O75396 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
SEC22B O75396 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
SEC22B O75396 DPM3 Homo sapiens Q9P2X0-2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 DPM3 Homo sapiens Q9P2X0-2
Validated Y2H
32296183
Intra
SEC22B O75396 DPM3 Homo sapiens Q9P2X0-2
Y2H Array
32296183
Intra
SEC22B O75396 MGST2 Homo sapiens Q99735
Validated Y2H
32296183
Intra
SEC22B O75396 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra
SEC22B O75396 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra
SEC22B O75396 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 HIBADH Homo sapiens P31937
Validated Y2H
32296183
Intra
SEC22B O75396 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
SEC22B O75396 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
SEC22B O75396 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
SEC22B O75396 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
SEC22B O75396 STX2 Homo sapiens P32856-2
Validated Y2H
32296183
Intra
SEC22B O75396 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
SEC22B O75396 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 AIG1 Homo sapiens Q9NVV5-2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
SEC22B O75396 AIG1 Homo sapiens Q9NVV5-2
Y2H Array
32296183
Intra
SEC22B O75396 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
SEC22B O75396 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
SEC22B O75396 TMEM229B Homo sapiens Q8NBD8
Y2H Array
32296183
Intra
SEC22B O75396 TMEM229B Homo sapiens Q8NBD8
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TMEM229B Homo sapiens Q8NBD8
Validated Y2H
32296183
Intra
SEC22B O75396 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
SEC22B O75396 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
SEC22B O75396 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SEC22B O75396 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SEC22B O75396 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
SEC22B O75396 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SEC22B O75396 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 GJB6 Homo sapiens O95452
Validated Y2H
32296183
Intra
SEC22B O75396 GJB6 Homo sapiens O95452
Y2H Array
32296183
Intra
SEC22B O75396 GJB6 Homo sapiens O95452
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CLRN1 Homo sapiens P58418
Validated Y2H
32296183
Intra
SEC22B O75396 CLRN1 Homo sapiens P58418
Y2H Array
32296183
Intra
SEC22B O75396 CLRN1 Homo sapiens P58418
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
SEC22B O75396 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
SEC22B O75396 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra
SEC22B O75396 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
SEC22B O75396 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
SEC22B O75396 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
SEC22B O75396 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
SEC22B O75396 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
SEC22B O75396 CERS6 Homo sapiens Q6ZMG9-2
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CERS6 Homo sapiens Q6ZMG9-2
Validated Y2H
32296183
Intra
SEC22B O75396 CERS6 Homo sapiens Q6ZMG9-2
Y2H Array
32296183
Intra
SEC22B O75396 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
SEC22B O75396 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SEC22B O75396 LHFPL1 Homo sapiens Q86WI0
Y2H Array
32296183
Intra
SEC22B O75396 LHFPL1 Homo sapiens Q86WI0
Validated Y2H
32296183
Intra
SEC22B O75396 LHFPL1 Homo sapiens Q86WI0
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
SEC22B O75396 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
SEC22B O75396 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
SEC22B O75396 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
SEC22B O75396 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
SEC22B O75396 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
SEC22B O75396 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
SEC22B O75396 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
SEC22B O75396 NDUFAF2 Homo sapiens Q8N183
Validated Y2H
32296183
Intra
SEC22B O75396 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
SEC22B O75396 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
SEC22B O75396 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
SEC22B O75396 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 ABHD16A Homo sapiens O95870
Validated Y2H
32296183
Intra
SEC22B O75396 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
SEC22B O75396 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 IFNGR2 Homo sapiens P38484
Validated Y2H
32296183
Intra
SEC22B O75396 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
SEC22B O75396 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 GJB5 Homo sapiens O95377
Validated Y2H
32296183
Intra
SEC22B O75396 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
SEC22B O75396 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
SEC22B O75396 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
SEC22B O75396 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra
SEC22B O75396 GORAB Homo sapiens Q5T7V8
Validated Y2H
32296183
Intra
SEC22B O75396 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra
SEC22B O75396 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra
SEC22B O75396 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
SEC22B O75396 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
SEC22B O75396 TM4SF19 Homo sapiens Q96DZ7
Validated Y2H
32296183
Intra
SEC22B O75396 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra
SEC22B O75396 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SEC22B O75396 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SEC22B O75396 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
SEC22B O75396 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
SEC22B O75396 STX5 Homo sapiens Q13190
Anti Tag CoIP
33961781
Intra
SEC22B O75396 STX5 Homo sapiens Q13190
Anti Bait CoIP
22153078
Intra
SEC22B O75396 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra
SEC22B O75396 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
SEC22B O75396 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
SEC22B O75396 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
33961781
Intra
SEC22B O75396 STX18 Homo sapiens Q9P2W9
Anti Tag CoIP
28514442
Intra
SEC22B O75396 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
SEC22B O75396 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
SEC22B O75396 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 STX4 Homo sapiens Q12846
Validated Y2H
32296183
Intra
SEC22B O75396 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra
SEC22B O75396 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
Intra
SEC22B O75396 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
Intra
SEC22B O75396 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
SEC22B O75396 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
SEC22B O75396 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
SEC22B O75396 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SEC22B O75396 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SEC22B O75396 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SEC22B O75396 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
SEC22B O75396 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
SEC22B O75396 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 RHBDD1 Homo sapiens Q8TEB9
Y2H Array
32296183
Intra
SEC22B O75396 RHBDD1 Homo sapiens Q8TEB9
Y2H Prey Pooling
32296183
Intra
SEC22B O75396 RHBDD1 Homo sapiens Q8TEB9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection
Pontiac Fever
Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12611 SEC22B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SEC22B VGNC VGNC:59190
Rattus norvegicus SEC22B RGD RGD:1309988
Felis catus SEC22B VGNC VGNC:99810
Mus musculus SEC22B MGD MGI:1338759
Canis familiaris SEC22B VGNC VGNC:99805