PRKAG3 - protein kinase AMP-activated non-catalytic subunit gamma 3 Gene

Homo sapiens

Also known as AMPKG3; SMGMQTL

Gene ID: 53632 | Gene type: protein coding

About PRKAG3

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,822,308-218,831,803 (from NCBI)

This gene has 6 transcripts (splice variants), 262 orthologues, 2 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]

PRKAG3 Products(1)

mRNA	Protein	Name
NM_017431.4	NP_059127.2	5'-AMP-activated protein kinase subunit gamma-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	10698692	GOA
enables protein kinase regulator activity	IDA IDA: Inferred from direct assay	24563466	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	25412657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAG3 Protein Structure

CBS

0
100
200
300
400
489 a.a.

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase subunit gamma-3

5'-AMP-activated protein kinase, gamma-3 subunit

PRKAG3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PRKAG3	Q9UGI9	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	PRKAG3	Q9UGI9	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	PRKAG3	Q9UGI9	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	33961781
Intra	PRKAG3	Q9UGI9	PRKAB2	Homo sapiens	O43741	Y2H Array	32296183
Intra	PRKAG3	Q9UGI9	PRKAB2	Homo sapiens	O43741	Pull Down	32707033
Intra	PRKAG3	Q9UGI9	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	32296183
Intra	PRKAG3	Q9UGI9	PRKAB2	Homo sapiens	O43741	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skeletal Muscle Glycogen Content And Metabolism Quantitative Trait Locus

SMGMQTL

Skeletal Muscle Glycogen Content And Metabolism Qtl

Wolff-Parkinson-White Syndrome

Wolff-Parkinson-White Pattern	Wpw Syndrome
Anomalous Atrioventricular Excitation	Anomalous A-V Excitation
Ventricular Pre-Excitation With Arrhythmia	WPWS
Ventricular Familial Preexcitation Syndrome	Preexcitation Syndrome
Ventricular Preexcitation	Wpw - [Wolff-Parkinson- White] Syndrome
Pre-Excitation Syndrome

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11111	PRKAG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRKAG3	VGNC	VGNC:69049
Rattus norvegicus	PRKAG3	RGD	RGD:1308698
Bos taurus	PRKAG3	VGNC	VGNC:33323
Canis familiaris	PRKAG3	VGNC	VGNC:44974
Mus musculus	PRKAG3	MGD	MGI:1891343
Macaca mulatta	PRKAG3	VGNC	VGNC:76406
Others	PRKAG3	NCBI

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