POLE3 - DNA polymerase epsilon 3, accessory subunit Gene

Homo sapiens

Also known as p17; YBL1; CHRAC2; CHRAC17; CHARAC17

Gene ID: 54107 | Gene type: protein coding

About POLE3

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,407,235-113,410,749 (from NCBI)

This gene has 4 transcripts (splice variants) and 98 orthologues. Ubiquitous expression in bone marrow (RPKM 36.1), testis (RPKM 24.6) and 25 other tissues.

Summary

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

POLE3 Products(2)

mRNA	Protein	Name
NM_001278255.1	NP_001265184.1	DNA polymerase epsilon subunit 3
NM_017443.5	NP_059139.3	DNA polymerase epsilon subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10801849	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated DNA replication	IDA IDA: Inferred from direct assay	33051204	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	10880450	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in nucleosome assembly	IDA IDA: Inferred from direct assay	14759371	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	12434153	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA
part of epsilon DNA polymerase complex	IDA IDA: Inferred from direct assay	10801849	GOA
part of epsilon DNA polymerase complex	IPI IPI: Inferred from physical interaction	10801849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLE3 Protein Structure

CBFD_NFYB_HMF

0
100
147 a.a.

Protein Preferred Names

Protein Names

DNA polymerase epsilon subunit 3

CHRAC-17

Related Diseases

Diseases

Alias

Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type	VEODS
Mrxsveod	Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type
X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type

Macular Degeneration, Age-Related, 2

Age Related Macular Degeneration 2	ARMD2
Macular Degeneration, Senile	Maculopathy, Age-Related, 2
Macular Degeneration, Age-Related, 2, Susceptibility To	Macular Degeneration, Age-Related, Type 2

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10827	POLE3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	POLE3	VGNC	VGNC:64285
Rattus norvegicus	POLE3	RGD	RGD:1359475
Canis familiaris	POLE3	VGNC	VGNC:44780
Mus musculus	POLE3	MGD	MGI:1933378
Bos taurus	POLE3	VGNC	VGNC:33120

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