ERRFI1 - ERBB receptor feedback inhibitor 1 Gene

Homo sapiens

Also known as MIG6; RALT; MIG-6; GENE-33

Gene ID: 54206 | Gene type: protein coding

About ERRFI1

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:8,011,727-8,026,309 (from NCBI)

This gene has 5 transcripts (splice variants) and 259 orthologues. Broad expression in liver (RPKM 123.7), gall bladder (RPKM 60.1) and 20 other tissues.

Summary

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]

ERRFI1 Products(1)

mRNA	Protein	Name
NM_018948.4	NP_061821.1	ERBB receptor feedback inhibitor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15778465	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18046415	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	18046415	GOA
involved in negative regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	18046415	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERRFI1 Protein Structure

GTPase_binding

Inhibitor_Mig-6

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

ERBB receptor feedback inhibitor 1

mitogen-inducible gene 6 protein

ERRFI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ERRFI1	Q9UJM3	FYN	Homo sapiens	P06241-3	Y2H Prey Pooling	32296183
Intra	ERRFI1	Q9UJM3	FYN	Homo sapiens	P06241-3	Y2H Array	32296183
Intra	ERRFI1	Q9UJM3	EGFR	Homo sapiens	P00533	X-Ray Diffraction	18046415
Intra	ERRFI1	Q9UJM3	EGFR	Homo sapiens	P00533	Fluorescence Spectr	18046415
Intra	ERRFI1	Q9UJM3	EGFR	Homo sapiens	P00533	TAP	24189400
Intra	ERRFI1	Q9UJM3	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	32296183
Intra	ERRFI1	Q9UJM3	GRB2	Homo sapiens	P62993	TAP	24189400
Intra	ERRFI1	Q9UJM3	GRB2	Homo sapiens	P62993	Y2H Array	32296183
Intra	ERRFI1	Q9UJM3	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
Intra	ERRFI1	Q9UJM3	GRB2	Homo sapiens	P62993	Anti Tag CoIP	33961781
Intra	ERRFI1	Q9UJM3	SFN	Homo sapiens	P31947	Anti Tag CoIP	15778465
Intra	ERRFI1	Q9UJM3	ERBB2	Homo sapiens	P04626	Y2H Array	25640309
Intra	ERRFI1	Q9UJM3	ERBB2	Homo sapiens	P04626	TAP	24189400
Intra	ERRFI1	Q9UJM3	CHEK1	Homo sapiens	O14757	Enzymatic Study	22505024

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04516	ERRFI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ERRFI1	VGNC	VGNC:28598
Macaca mulatta	ERRFI1	VGNC	VGNC:99913
Rattus norvegicus	ERRFI1	RGD	RGD:1307599
Mus musculus	ERRFI1	MGD	MGI:1921405
Canis familiaris	ERRFI1	VGNC	VGNC:40469
Felis catus	ERRFI1	VGNC	VGNC:61958

Name
Email *

	Sorry, but the email address you supplied was invalid.