1. Gene
  2. TREM2 - triggering receptor expressed on myeloid cells 2 Gene

TREM2 - triggering receptor expressed on myeloid cells 2 Gene

Homo sapiens

Also known as PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c

Gene ID: 54209 | Gene type: protein coding

About TREM2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,158,508-41,163,116 (from NCBI)

This gene has 3 transcripts (splice variants), 111 orthologues, 13 paralogues and is associated with 8 phenotypes. Broad expression in brain (RPKM 11.5), lung (RPKM 7.7) and 14 other tissues.

Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

TREM2 Products(2)

mRNA Protein Name
NM_001271821.2 NP_001258750.1 triggering receptor expressed on myeloid cells 2 precursor isoform 2 precursor
NM_018965.4 NP_061838.1 triggering receptor expressed on myeloid cells 2 precursor isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
29518356 GOA
enables apolipoprotein A-I binding IPI
IPI: Inferred from physical interaction
27477018 GOA
enables apolipoprotein binding IPI
IPI: Inferred from physical interaction
27477018 GOA
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
30683932 GOA
enables high-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
27477018 GOA
enables kinase activator activity IMP
IMP: Inferred from mutant phenotype
31902528 GOA
enables lipoprotein particle binding IDA
IDA: Inferred from direct assay
27477018 GOA
enables low-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
27477018 GOA
enables phosphatidylethanolamine binding IDA
IDA: Inferred from direct assay
31101881 GOA
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
31101881 GOA
enables phospholipid binding IDA
IDA: Inferred from direct assay
27995897 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11602640 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
29518356 GOA
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
11602640 GOA
enables signaling receptor activity IMP
IMP: Inferred from mutant phenotype
32514138 GOA
enables sulfatide binding IDA
IDA: Inferred from direct assay
31902528 GOA
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
29518356 GOA
enables very-low-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
27477018 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive effect CXCL12-activated CXCR4 signaling pathway IMP
IMP: Inferred from mutant phenotype
33097708 GOA
involved in amyloid-beta clearance IDA
IDA: Inferred from direct assay
27477018 GOA
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
33097708 GOA
involved in cellular response to amyloid-beta IDA
IDA: Inferred from direct assay
29518356 GOA
involved in cellular response to lipid IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in cellular response to lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
27477018 GOA
involved in cellular response to oxidised low-density lipoprotein particle stimulus IDA
IDA: Inferred from direct assay
31902528 GOA
involved in dendritic cell differentiation IDA
IDA: Inferred from direct assay
11602640 GOA
acts upstream of positive effect memory IDA
IDA: Inferred from direct assay
31462511 GOA
acts upstream of positive effect memory IMP
IMP: Inferred from mutant phenotype
29518357 GOA
acts upstream of or within negative regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in negative regulation of macrophage colony-stimulating factor signaling pathway IMP
IMP: Inferred from mutant phenotype
33097708 GOA
involved in negative regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
30683932 GOA
acts upstream of or within osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
21841309 GOA
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12925681 GOA
involved in phagocytosis, recognition IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in positive regulation of C-C chemokine receptor CCR7 signaling pathway IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of CD40 signaling pathway IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
27995897 GOA
involved in positive regulation of amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
31235932 GOA
involved in positive regulation of antigen processing and presentation of peptide antigen via MHC class II IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of engulfment of apoptotic cell IMP
IMP: Inferred from mutant phenotype
24990881 GOA
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in positive regulation of kinase activity IDA
IDA: Inferred from direct assay
31902528 GOA
involved in positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
24990881 GOA
involved in positive regulation of microglial cell migration IMP
IMP: Inferred from mutant phenotype
33097708 GOA
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
32514138 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
29518357 GOA
acts upstream of positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in positive regulation of phagocytosis, engulfment IMP
IMP: Inferred from mutant phenotype
28855300 GOA
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
11602640 GOA
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
27044754 GOA
involved in positive regulation of synapse pruning IMP
IMP: Inferred from mutant phenotype
33097708 GOA
acts upstream of regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
32514138 GOA
involved in regulation of plasma membrane bounded cell projection organization IGI
IGI: Inferred from genetic interaction
29518356 GOA
involved in response to axon injury IMP
IMP: Inferred from mutant phenotype
31235932 GOA
acts upstream of positive effect social behavior IMP
IMP: Inferred from mutant phenotype
29752066 GOA
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
11602640 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
24078628 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
27995897 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
24990881 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
31413141 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREM2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (22 - 121)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

triggering receptor expressed on myeloid cells 2

triggering receptor expressed on monocytes 2

Recombinant TREM2 Proteins

Cat. No. Product Name Accession Purity
HY-P70534 TREM-2 Protein, Human (HEK293, His) Q9NZC2-1 (H19-S174) ≥95%
HY-P78222 TREM-2 Protein, Human (Biotinylated, HEK293, His-Avi) Q9NZC2-1 (H19-S174) ≥95%

Related Diseases

Diseases Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2

PLOSL2

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Solitary Bone Cyst

Unicameral Bone Cyst

Bone Cysts

Cyst Of Bone

Local Cyst Of Bone

Simple Bone Cyst

Solitary Bone Cyst, Unspecified Site

Traumatic Bone Cyst

Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease

Early-Onset, Autosomal Dominant Alzheimer Disease

Familial Alzheimer Disease

Early-Onset Autosomal Dominant Alzheimer Disease

Eofad

Early-Onset Familial Autosomal Dominant Alzheimer Disease

Alzheimer'S Disease, Familial

Progressive Non-Fluent Aphasia

Non-Fluent Variant Ppa

Progressive Nonfluent Aphasia

Non-Fluent Primary Progressive Aphasia

Agramatic Variant Of Ppa

Agramatic Variant Of Primary Progressive Aphasia

Primary Progressive Non Fluent Aphasia

Primary Progressive Nonfluent Aphasia

Basal Ganglia Calcification

Fahr'S Syndrome

Fahr'S Disease

Fahr Disease

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Maxillary Sinusitis
Parkinson Disease 23, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 23

PARK23

Parkinson Disease 23, Autosomal Recessive, Early Onset

Parkinson'S Disease 23

Autosomal Recessive Early-Onset Parkinson'S Disease 23

Parkinson Disease, Type 23, Autosomal Recessive, Early Onset

Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1

Hereditary Diffuse Leukoencephalopathy With Spheroids

Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Alsp

Gpsc

Subcortical Gliosis Of Neumann

Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1

Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids

Hdls

HDLS1

Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia

Gliosis, Familial Progressive Subcortical

Leukoencephalopathy, Diffuse Hereditary, With Spheroids

Pold

Pigmentary Orthochromatic Leukodystrophy

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia

Familial Progressive Subcortical Gliosis

Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant

Dementia, Familial, Neumann Type

Adult-Onset Leukodystrophy With Neuroaxonal Spheroids

Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids

Neuroaxonal Leukodystrophy

Fpsg

Familial Dementia, Neumann Type

Familial Dementia Neumann Type

Leukoencephalopathy, Diffuse Hereditary, With Spheroid

Amyotrophic Lateral Sclerosis 3

ALS3

Amyotrophic Lateral Sclerosis Type 3

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Mild Cognitive Impairment
Subjective Cognitive Decline
Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Cerebral Degeneration

Brain Degeneration

Degenerative Brain Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta TREM2 VGNC VGNC:79089
Felis catus TREM2 VGNC VGNC:66519
Rattus norvegicus TREM2 RGD RGD:1309841
Canis familiaris TREM2 VGNC VGNC:47794
Bos taurus TREM2 VGNC VGNC:36299
Mus musculus TREM2 MGD MGI:1913150
Macaca fascicularis TREM2 NCBI NCBI:102133279
Others TREM2 NCBI