Fgf2 - fibroblast growth factor 2 Gene

Rattus norvegicus

Also known as bFGF; Fgf-2; Fgf2a

Gene ID: 54250 | Gene type: protein coding

About Fgf2

Summary

Enables Fibroblast Growth Factor receptor binding activity. Involved in several processes, including angiogenesis involved in coronary vascular morphogenesis; paracrine signaling; and positive regulation of cell population proliferation. Acts upstream of or within Fibroblast Growth Factor receptor signaling pathway. Located in cytoplasm; extracellular space; and nucleus. Used to study pulmonary hypertension. Biomarker of bladder disease; decubitus ulcer; diabetic retinopathy; hypertension; and retinal vein occlusion. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (Fibroblast Growth Factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgf2 Products(1)

mRNA	Protein	Name
NM_019305.2	NP_062178.1	fibroblast growth factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables H3K9me3 modified histone binding	IDA IDA: Inferred from direct assay	25071177	RGD
enables fibroblast growth factor receptor binding	IPI IPI: Inferred from physical interaction	10766846	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12397076	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis involved in coronary vascular morphogenesis	IMP IMP: Inferred from mutant phenotype	11397779	RGD
involved in behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	28821667	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19012730	RGD
involved in embryo development ending in birth or egg hatching	IMP IMP: Inferred from mutant phenotype	19476451	RGD
acts upstream of or within fibroblast growth factor receptor signaling pathway	IPI IPI: Inferred from physical interaction	10766846	RGD
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	25426952	RGD
involved in paracrine signaling	IDA IDA: Inferred from direct assay	28679962	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	8603495	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12000311	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	9854551	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	28821667	RGD
involved in response to wortmannin	IMP IMP: Inferred from mutant phenotype	31375540	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21543745	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 2

HBGF-2	angiogenesis promoting growth factor
basic fibroblast growth factor	fibroblast growth factor 2a
heparin binding growth factor	heparin-binding growth factor 2

Recombinant Fgf2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7091	FGF-2 Protein, Rat	P13109 (A11-S154)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122704A	Surfen dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-107753	XRP44X	Inhibitor	98.09%	Unkown
HY-107194	NSC12	Inhibitor	99.07%	Unkown
HY-P5133	Synstatin (92-119)	Inhibitor	97.16%	Unkown
HY-102071	KIN59	Inhibitor	≥99.0%	Unkown
HY-RS04896	FGF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116030	JNJ-26076713	Antagonist	/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-123541	Tec-IN-6	Inhibitor	/	Unkown
HY-124827	Tec-IN-1	Inhibitor	/	Unkown
HY-161840	Antitumor agent-176	Inhibitor	/	Unkown
HY-161841	Antitumor agent-177	Inhibitor	/	Unkown
HY-P10301	CXCL9(74-103)		/	Unkown
HY-118184	AF3485	Inhibitor	/	Unkown
HY-122704	Surfen	Inhibitor	/	Unkown
HY-123453	SM27	Inhibitor	/	Unkown
HY-138257A	(R)-Indeloxazine benzenesulfonate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf2	NCBI	NCBI:2247
Macaca fascicularis	Fgf2	NCBI	NCBI:102133679
Mus musculus	Fgf2	NCBI	NCBI:14173
Susscrofa domestica	Fgf2	NCBI

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