Fgf2 - fibroblast growth factor 2 Gene

Mus musculus

Also known as Fgfb; bFGF; Fgf-2; Fgf2a

Gene ID: 14173 | Gene type: protein coding

About Fgf2

Summary

Enables growth factor activity. Involved in stem cell development. Acts upstream of or within several processes, including animal organ development; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; corneal neovascularization; diabetic neuropathy; gastric ulcer; and impotence. Orthologous to human FGF2 (Fibroblast Growth Factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fgf2 Products(1)

mRNA	Protein	Name
NM_008006.2	NP_032032.1	fibroblast growth factor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	15608665	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8393815	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16858399	MGI
acts upstream of angiogenesis	IGI IGI: Inferred from genetic interaction	16648142	MGI
acts upstream of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16858399	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	16141225	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	10027293	MGI
acts upstream of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within corticotropin hormone secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of endothelial cell migration	IDA IDA: Inferred from direct assay	16291864	MGI
acts upstream of endothelial cell proliferation	IDA IDA: Inferred from direct assay	16291864	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17187775	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within glial cell differentiation	IMP IMP: Inferred from mutant phenotype	12878680	MGI
acts upstream of inner ear auditory receptor cell differentiation	IDA IDA: Inferred from direct assay	12417662	MGI
acts upstream of or within lung development	IDA IDA: Inferred from direct assay	15576401	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	17187775	MGI
acts upstream of lymphatic endothelial cell migration	IDA IDA: Inferred from direct assay	16291864	MGI
acts upstream of or within mammary gland epithelial cell differentiation	IDA IDA: Inferred from direct assay	1376141	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10027293	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	15051883	MGI
acts upstream of neuroepithelial cell differentiation	IDA IDA: Inferred from direct assay	12417662	MGI
acts upstream of or within organ induction	IDA IDA: Inferred from direct assay	15576401	MGI
acts upstream of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16858399	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16858399	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	29501879	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	16339969	MGI
acts upstream of or within positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	14702107	MGI
acts upstream of or within positive regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	12759260	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16858399	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	16291864	MGI
acts upstream of or within positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	16291864	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	17187775	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	9244299	MGI
acts upstream of or within positive regulation of inner ear auditory receptor cell differentiation	IDA IDA: Inferred from direct assay	12417662	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	15051883	MGI
acts upstream of or within positive regulation of neuroepithelial cell differentiation	IDA IDA: Inferred from direct assay	12417662	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16858399	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15608665	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	29501879	MGI
acts upstream of or within positive regulation of stem cell differentiation	IDA IDA: Inferred from direct assay	15781473	MGI
acts upstream of or within positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	16141225	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9102311	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8898217	MGI
acts upstream of or within regulation of cell cycle	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of or within regulation of retinal cell programmed cell death	IDA IDA: Inferred from direct assay	11747369	MGI
acts upstream of or within response to axon injury	IMP IMP: Inferred from mutant phenotype	16009496	MGI
involved in stem cell development	IMP IMP: Inferred from mutant phenotype	12843296	MGI
acts upstream of stem cell differentiation	IDA IDA: Inferred from direct assay	15781473	MGI
acts upstream of stem cell proliferation	IDA IDA: Inferred from direct assay	16141225	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	20570969	MGI
acts upstream of or within substantia nigra development	IMP IMP: Inferred from mutant phenotype	17234579	MGI
acts upstream of or within thyroid-stimulating hormone-secreting cell differentiation	IDA IDA: Inferred from direct assay	9463347	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10391928	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	12417662	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 2

HBGF-2	basic fibroblast growth factor
fibroblast growth factor 2a	heparin-binding growth factor 2

Recombinant Fgf2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7066	FGF-2 Protein, Mouse (145a.a)	P15655 (P10-S154)	≥95%
HY-P70439	FGF-2 Protein, Mouse (154a.a)	P15655 (M1-S154)	≥95%
HY-P73052	FGF-2 Protein, Mouse (His)	NP_032032.1 (A11-S154)	≥95%
HY-P73052AF	Animal-Free FGF-2 Protein, Mouse (His)	P15655 (A11-S154)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122704A	Surfen dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-107753	XRP44X	Inhibitor	98.42%	Unkown
HY-107194	NSC12	Inhibitor	99.07%	Unkown
HY-P5133	Synstatin (92-119)	Inhibitor	97.16%	Unkown
HY-102071	KIN59	Inhibitor	≥99.0%	Unkown
HY-RS04896	FGF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116030	JNJ-26076713	Antagonist	/	Unkown
HY-118792	AHR activator 1		/	Unkown
HY-123541	Tec-IN-6	Inhibitor	/	Unkown
HY-124827	Tec-IN-1	Inhibitor	/	Unkown
HY-161840	Antitumor agent-176	Inhibitor	/	Unkown
HY-161841	Antitumor agent-177	Inhibitor	/	Unkown
HY-118184	AF3485	Inhibitor	/	Unkown
HY-122704	Surfen	Inhibitor	/	Unkown
HY-123453	SM27	Inhibitor	/	Unkown
HY-138257A	(R)-Indeloxazine benzenesulfonate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf2	NCBI	NCBI:2247
Macaca fascicularis	Fgf2	NCBI	NCBI:102133679
Susscrofa domestica	Fgf2	NCBI
Rattus norvegicus	Fgf2	NCBI	NCBI:54250

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