Phc2 - polyhomeotic 2 Gene

Mus musculus

Also known as p36; Edr2; Mph2; A3galt2; D4Ertd810e; D130050K19Rik

Gene ID: 54383 | Gene type: protein coding

About Phc2

Summary

Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in heterochromatin and nucleus. Part of PcG protein complex. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2). [provided by Alliance of Genome Resources, Apr 2022]

Phc2 Products(3)

mRNA	Protein	Name
NM_001195083.1	NP_001182012.1	polyhomeotic-like protein 2 isoform B
NM_001195130.1	NP_001182059.1	polyhomeotic-like protein 2 isoform A
NM_018774.4	NP_061244.1	polyhomeotic-like protein 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9627119	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	17215307	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	16359901	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	18311137	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12034499	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polyhomeotic-like protein 2

early development regulator 2	early development regulatory protein 2
polyhomeotic 2 protein	polyhomeotic-like 2

Phc2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Phc2	Q9QWH1	Mapkapk2	Mus musculus	P49138	Pull Down	19369945
Intra	Phc2	Q9QWH1	Mapkapk2	Mus musculus	P49138	Y2H	19369945
Intra	Phc2	Q9QWH1	Pcgf2	Mus musculus	P23798	Anti Bait CoIP	16024804
Intra	Phc2	Q9QWH1	Pcgf2	Mus musculus	P23798	Y2H	12034499
Intra	Phc2	Q9QWH1	Rnf2	Mus musculus	Q9CQJ4	Anti Bait CoIP	16024804
Intra	Phc2	Q9QWH1	Phc1	Mus musculus	Q64028	Anti Bait CoIP	16024804
Cross	Phc2	Q9QWH1	MAPKAPK2	Homo sapiens	P49137	Pull Down	19369945

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10410	PHC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phc2	NCBI	NCBI:1912

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