PHC2 - polyhomeotic homolog 2 Gene

Homo sapiens

Also known as PH2; EDR2; HPH2

Gene ID: 1912 | Gene type: protein coding

About PHC2

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:33,323,626-33,431,095 (from NCBI)

This gene has 13 transcripts (splice variants), 149 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 13.8), endometrium (RPKM 13.8) and 25 other tissues.

Summary

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PHC2 Products(10)

mRNA	Protein	Name
NM_001330488.2	NP_001317417.1	polyhomeotic-like protein 2 isoform c
NM_001385109.1	NP_001372038.1	polyhomeotic-like protein 2 isoform e
NM_001385112.1	NP_001372041.1	polyhomeotic-like protein 2 isoform d
NM_001385119.1	NP_001372048.1	polyhomeotic-like protein 2 isoform e
NM_001385120.1	NP_001372049.1	polyhomeotic-like protein 2 isoform e
NM_001385121.1	NP_001372050.1	polyhomeotic-like protein 2 isoform f
NM_001385122.1	NP_001372051.1	polyhomeotic-like protein 2 isoform c
NM_001385123.1	NP_001372052.1	polyhomeotic-like protein 2 isoform g
NM_004427.4	NP_004418.2	polyhomeotic-like protein 2 isoform b
NM_198040.3	NP_932157.1	polyhomeotic-like protein 2 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10976766	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	12167701	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHC2 Protein Structure

SAM_1

0
200
400
600
800
858 a.a.

Protein Preferred Names

Protein Names

polyhomeotic-like protein 2

early development regulator 2 (homolog of polyhomeotic 2)

Related Diseases

Diseases

Alias

Conventional Angiosarcoma

Akinetopsia

Form Agnosia

Pontocerebellar Hypoplasia, Type 12

PCH12	Pontocerebellar Hypoplasia Type 12
Coasy-Related Pontocerebellar Hypoplasia	Pontocerebellar Hypoplasia 12
Doid:0112327	Hypoplasia, Pontocerebellar, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10410	PHC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHC2	VGNC	VGNC:64134
Mus musculus	PHC2	MGD	MGI:1860454
Canis familiaris	PHC2	VGNC	VGNC:44478
Rattus norvegicus	PHC2	RGD	RGD:1307912
Macaca mulatta	PHC2	VGNC	VGNC:75903
Bos taurus	PHC2	VGNC	VGNC:32811

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