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  3. MAPKAPK2 - MAPK activated protein kinase 2 Gene

MAPKAPK2 - MAPK activated protein kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MK2; MK-2; MAPKAP-K2

Gene ID: 9261 | Gene type: protein coding

About MAPKAPK2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,684,905-206,734,281 (from NCBI)

This gene has 4 transcripts (splice variants), 238 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 54.9), heart (RPKM 45.1) and 25 other tissues.

Summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MAPKAPK2 Products(5)

mRNA Protein Name
NM_004759.5 NP_004750.1 MAP kinase-activated protein kinase 2 isoform 1
XM_047434418.1 XP_047290374.1 MAP kinase-activated protein kinase 2 isoform X3
XM_005273353.4 XP_005273410.1 MAP kinase-activated protein kinase 2 isoform X1
XM_017002810.2 XP_016858299.1 MAP kinase-activated protein kinase 2 isoform X2
NM_032960.4 NP_116584.2 MAP kinase-activated protein kinase 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
8774846 GOA
enables protein serine/threonine kinase activity EXP
EXP: Inferred from Experiment
7799959 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8774846 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-UTR-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
14517288 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
20932473 GOA
involved in cellular response to vascular endothelial growth factor stimulus IMP
IMP: Inferred from mutant phenotype
18440775 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
15850461 GOA
involved in regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
15014438 GOA
involved in response to cytokine IDA
IDA: Inferred from direct assay
8774846 GOA
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18440775 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20932473 GOA
located in nucleus IDA
IDA: Inferred from direct assay
20932473 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPKAPK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (67 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 2

MAPKAP kinase 2

mitogen-activated protein kinase-activated protein kinase 2

MAPKAPK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MAPKAPK2 P49137 HSPB1 Homo sapiens P04792
Protein Kinase Assay
21575178
Cross
MAPKAPK2 P49137 Phc2 Mus musculus Q9QWH1
Pull Down
19369945
Intra
MAPKAPK2 P49137 HSF1 Homo sapiens Q00613
GMS
16278218
Intra
MAPKAPK2 P49137 MAPK14 Homo sapiens Q16539
Y2H
21988832
Intra
MAPKAPK2 P49137 MAPK14 Homo sapiens Q16539
PLA
25241761
Intra
MAPKAPK2 P49137 MAPK14 Homo sapiens Q16539
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Monocytic Leukemia

Monocytic Leukaemia

Schilling'S Leukaemia

Schilling'S Leukemia

M5b Acute Differentiated Monocytic Leukemia
Retinitis Pigmentosa 58

RP58

Retinitis Pigmentosa, Type 58
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107427 PF-3644022 Inhibitor 99.65% Unkown
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.36% Unkown
HY-131249 MK2-IN-3 Inhibitor 99.58% Unkown
HY-148063 DB0614 98.80% Unkown
HY-112457 MK2-IN-3 hydrate Inhibitor ≥99.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-12834 MK2-IN-1 Inhibitor 99.04% Unkown
HY-147283 MK2-IN-4 Inhibitor / Unkown
HY-P10367 Ziptide / Unkown
HY-RS08131 MAPKAPK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08132 Mapkapk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08133 Mapkapk2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MAPKAPK2 VGNC VGNC:54449
Rattus norvegicus MAPKAPK2 RGD RGD:631362
Macaca mulatta MAPKAPK2 VGNC VGNC:74653
Mus musculus MAPKAPK2 MGD MGI:109298
Felis catus MAPKAPK2 VGNC VGNC:68175
Canis familiaris MAPKAPK2 VGNC VGNC:43006
Others MAPKAPK2 NCBI