SSH1 - slingshot protein phosphatase 1 Gene

Homo sapiens

Also known as SSH1L

Gene ID: 54434 | Gene type: protein coding

About SSH1

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,778,191-108,857,583 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 30 paralogues. Ubiquitous expression in gall bladder (RPKM 6.2), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

SSH1 Products(3)

mRNA	Protein	Name
NM_001161330.2	NP_001154802.1	protein phosphatase Slingshot homolog 1 isoform 2
NM_001161331.1	NP_001154803.1	protein phosphatase Slingshot homolog 1 isoform 3
NM_018984.4	NP_061857.3	protein phosphatase Slingshot homolog 1 isoform 1

SSH1 Protein Structure

DEK_C

DSPc

0
200
400
600
800
1049 a.a.

Protein Preferred Names

Protein Names

protein phosphatase Slingshot homolog 1

SSH-like protein 1

SSH1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSH1	Q8WYL5	CORO1B	Homo sapiens	Q9BR76	Phosphatase Assay	17350576
Intra	SSH1	Q8WYL5	CORO1B	Homo sapiens	Q9BR76	Anti Tag CoIP	17350576
Intra	SSH1	Q8WYL5	CFL1	Homo sapiens	P23528	Pull Down	21525957
Intra	SSH1	Q8WYL5	YWHAB	Homo sapiens	P31946	CoIP	19329994
Intra	SSH1	Q8WYL5	YWHAQ	Homo sapiens	P27348	Pull Down	15660133
Intra	SSH1	Q8WYL5	YWHAQ	Homo sapiens	P27348	CoIP	19371722
Intra	SSH1	Q8WYL5	LIMK1	Homo sapiens	P53667	Imaging	15660133
Intra	SSH1	Q8WYL5	LIMK1	Homo sapiens	P53667	Anti Tag CoIP	15660133
Intra	SSH1	Q8WYL5	LIMK1	Homo sapiens	P53667	Anti Bait CoIP	15660133
Intra	SSH1	Q8WYL5	LIMK1	Homo sapiens	P53667	CoIP	15660133
Intra	SSH1	Q8WYL5	LIMK1	Homo sapiens	P53667	Pull Down	15660133

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Marginal Corneal Ulcer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13809	SSH1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSH1	VGNC	VGNC:46831
Macaca mulatta	SSH1	VGNC	VGNC:78017
Rattus norvegicus	SSH1	RGD	RGD:1306038
Bos taurus	SSH1	VGNC	VGNC:35312
Mus musculus	SSH1	MGD	MGI:2686240
Felis catus	SSH1	VGNC	VGNC:65703

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