1. Gene
  2. FBXO42 - F-box protein 42 Gene

FBXO42 - F-box protein 42 Gene

Homo sapiens

Also known as JFK; Fbx42

Gene ID: 54455 | Gene type: protein coding

About FBXO42

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:16,246,840-16,352,480 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 6.4), fat (RPKM 5.1) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]

FBXO42 Products(1)

mRNA Protein Name
NM_018994.3 NP_061867.1 F-box only protein 42
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25609649 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO42 Protein Structure

F-box-like

F-box-like: F-box-like (48 - 82)

Kelch_3

Kelch_3: Galactose oxidase, central domain (131 - 182)

Kelch_2

Kelch_2: Kelch motif (231 - 274)

  • 0
  • 200
  • 400
  • 600
  • 717 a.a.
Protein Preferred Names Protein Names

F-box only protein 42

just one F-box and Kelch domain-containing protein

FBXO42 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXO42 Q6P3S6 GSK3A Homo sapiens P49840
Anti Tag CoIP
33961781
Intra
FBXO42 Q6P3S6 GSK3A Homo sapiens P49840
Anti Tag CoIP
28514442
Intra
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
FBXO42 Q6P3S6 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Validated Y2H
32814053
Intra
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Y2H Array
32814053
Intra
FBXO42 Q6P3S6 TPP1 Homo sapiens O14773
Y2H Pooling
32814053
Intra
FBXO42 Q6P3S6 RBPJ Homo sapiens Q06330
Anti Tag CoIP
33961781
Intra
FBXO42 Q6P3S6 RBPJ Homo sapiens Q06330
TAP
25609649
Intra
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
FBXO42 Q6P3S6 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Validated Y2H
32814053
Intra
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Y2H Pooling
32814053
Intra
FBXO42 Q6P3S6 NDUFV1 Homo sapiens P49821
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Desmoid Disease, Hereditary

Fif

DESMD

Hereditary Desmoid Disease

Familial Infiltrative Fibromatosis

Fibromatosis, Familial Infiltrative

Fibromatosis, Aggressive

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome

Pallidopyramidal Syndrome

Parkinson Disease 15, Autosomal Recessive

PARK15

Pkps

Pallido-Pyramidal Syndrome

Parkinson'S Disease 15

Autosomal Recessive Early-Onset Parkinson Disease 15

Autosomal Recessive Early-Onset Parkinson'S Disease 15

Pallido-Pyramidal Disease

Parkinson Disease 15

Parkinson Disease 15 Autosomal Recessive

Pps

Parkinson Disease, Type 15

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXO42 RGD RGD:1304787
Macaca mulatta FBXO42 VGNC VGNC:72597
Mus musculus FBXO42 MGD MGI:1924992
Bos taurus FBXO42 VGNC VGNC:28913
Felis catus FBXO42 VGNC VGNC:62194
Canis familiaris FBXO42 VGNC VGNC:40782