GNL3L - G protein nucleolar 3 like Gene

Homo sapiens

Also known as GNL3B

Gene ID: 54552 | Gene type: protein coding

About GNL3L

Cytogenetic location: Xp11.22 Genomic coordinates (GRCh38): X:54,530,219-54,645,854 (from NCBI)

This gene has 12 transcripts (splice variants), 188 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 3.6), appendix (RPKM 3.3) and 25 other tissues.

Summary

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GNL3L Products(2)

mRNA	Protein	Name
NM_001184819.2	NP_001171748.1	guanine nucleotide-binding protein-like 3-like protein
NM_019067.6	NP_061940.1	guanine nucleotide-binding protein-like 3-like protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	19487455	GOA
involved in negative regulation of protein sumoylation	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	19487455	GOA
involved in negative regulation of telomere maintenance via telomerase	IMP IMP: Inferred from mutant phenotype	18082603	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IDA IDA: Inferred from direct assay	19487455	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	19487455	GOA
involved in positive regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	19487455	GOA
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	19487455	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	19487455	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	18082603	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNL3L Protein Structure

MMR_HSR1

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein-like 3-like protein

G protein nucleolar 3B

GNL3L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNL3L	Q9NVN8	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	GNL3L	Q9NVN8	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	31515488
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	25416956
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	25416956
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	25416956
Intra	GNL3L	Q9NVN8	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	21132010
Intra	GNL3L	Q9NVN8	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	21132010
Intra	GNL3L	Q9NVN8	MDM2	Homo sapiens	Q00987	Confocal	21132010
Intra	GNL3L	Q9NVN8	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	GNL3L	Q9NVN8	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	GNL3L	Q9NVN8	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	GNL3L	Q9NVN8	LDOC1	Homo sapiens	O95751	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05567	GNL3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GNL3L	VGNC	VGNC:41328
Mus musculus	GNL3L	MGD	MGI:2448557
Felis catus	GNL3L	VGNC	VGNC:62627
Rattus norvegicus	GNL3L	RGD	RGD:1600217
Macaca mulatta	GNL3L	VGNC	VGNC:73011
Bos taurus	GNL3L	VGNC	VGNC:29474

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