RNF111 - ring finger protein 111 Gene

Homo sapiens

Also known as ARK; hRNF111

Gene ID: 54778 | Gene type: protein coding

About RNF111

Cytogenetic location: 15q22.1-q22.2 Genomic coordinates (GRCh38): 15:58,987,663-59,097,419 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 5.8), brain (RPKM 5.5) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin Ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

RNF111 Products(5)

mRNA	Protein	Name
NM_001270528.2	NP_001257457.1	E3 ubiquitin-protein ligase Arkadia isoform 1
NM_001270529.2	NP_001257458.1	E3 ubiquitin-protein ligase Arkadia isoform 3
NM_001270530.2	NP_001257459.1	E3 ubiquitin-protein ligase Arkadia isoform 4
NM_001330331.2	NP_001317260.1	E3 ubiquitin-protein ligase Arkadia isoform 5
NM_017610.8	NP_060080.6	E3 ubiquitin-protein ligase Arkadia isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO polymer binding	IDA IDA: Inferred from direct assay	23086935	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16601693	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	16601693	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16601693	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF111 Protein Structure

RNF111_N

zf-RING_2

0
200
400
600
800
994 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Arkadia

Arkadia

RNF111 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF111	Q6ZNA4	b2r8y4_human	Homo sapiens	B2R8Y4	Validated Y2H	25416956
Intra	RNF111	Q6ZNA4	b2r8y4_human	Homo sapiens	B2R8Y4	Y2H Prey Pooling	25416956
Intra	RNF111	Q6ZNA4	b2r8y4_human	Homo sapiens	B2R8Y4	Y2H Array	25416956
Intra	RNF111	Q6ZNA4	EDARADD	Homo sapiens	Q8WWZ3	Y2H Prey Pooling	25416956
Intra	RNF111	Q6ZNA4	CSNK2A1	Homo sapiens	P68400	Anti Tag CoIP	33961781
Intra	RNF111	Q6ZNA4	CSNK2A1	Homo sapiens	P68400	Y2H	21516116
Intra	RNF111	Q6ZNA4	CSNK2A1	Homo sapiens	P68400	Y2H Array	25416956
Intra	RNF111	Q6ZNA4	CSNK2A1	Homo sapiens	P68400	Y2H Array	29892012
Intra	RNF111	Q6ZNA4	UBE2D3	Homo sapiens	P61077	Y2H Array	25416956
Intra	RNF111	Q6ZNA4	UBE2D3	Homo sapiens	P61077	Y2H Array	19549727
Intra	RNF111	Q6ZNA4	UBE2D3	Homo sapiens	P61077	Y2H Prey Pooling	25416956
Intra	RNF111	Q6ZNA4	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	RNF111	Q6ZNA4	KRTAP5-9	Homo sapiens	P26371	Y2H Array	31515488
Intra	RNF111	Q6ZNA4	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	16601693
Intra	RNF111	Q6ZNA4	UBE2D1	Homo sapiens	P51668	Y2H Array	19690564
Intra	RNF111	Q6ZNA4	UBE2D1	Homo sapiens	P51668	Validated Y2H	25416956
Intra	RNF111	Q6ZNA4	UBE2I	Homo sapiens	P63279	Y2H Array	25416956
Intra	RNF111	Q6ZNA4	UBE2I	Homo sapiens	P63279	Y2H Pooling	20936779
Intra	RNF111	Q6ZNA4	UBE2I	Homo sapiens	P63279	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12036	RNF111 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF111	RGD	RGD:1310097
Macaca mulatta	RNF111	VGNC	VGNC:76751
Mus musculus	RNF111	MGD	MGI:1934919
Canis familiaris	RNF111	VGNC	VGNC:45621
Felis catus	RNF111	VGNC	VGNC:64663
Bos taurus	RNF111	VGNC	VGNC:34010

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